COMPUTATIONAL ANATOMY FOR NEURODEGENERATIVE BRAIN PATTERNS

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 该项目的总体目标是开发一个统计多模态人群脑图谱构建框架，其中包含所有可用的成像模式。该框架将支持的成像模式是T1、T2、各种扩散加权协议（如DWI和DSI）以及动脉自旋标记灌注MRI。该图谱构建框架将用于研究衰老大脑的解剖结构以及各种疾病对衰老过程的影响。特别是，概率脑图谱的生成将提高通过利用局部脑变异性的信息来识别疾病和老化脑之间的系统性脑差异的能力。此外，包括来自所有成像模态的联合信息的概率脑图谱将允许比单独使用单个图像模态或多个模态的常规方法更全面地调查脑改变。此外，将多模态图像数据映射到公共3D坐标空间是P41的许多成像分析项目的先决条件，因为它提供了一个定量空间参考系统，其中可以比较和关联来自多个受试者和模态的大脑数据。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The overall goal of the project is to develop a statistical multi-modal population brain atlas construction framework incorporating all the available imaging modalities. The imaging modalities that the framework will support are T1, T2, various diffusion weighted protocols such as DWI and DSI as well as arterial spin labeling perfusion MRI. The atlas construction framework will be used to study the anatomy of the aging brain and impact of various diseases on the aging process. In particular, the generation of probabilistic brain atlases will improve power to identify systematic brain differences between diseases and aging brains by utilizing information of local brain variability. Moreover, a probabilistic brain atlas that includes jointly information from all imaging modalities will allow more comprehensive investigations in brain alterations than conventional methods that use a single image modality or multiple modalities separately. Moreover, the mapping of multimodal image data into a common 3D coordinate space is a prerequisite for many imaging analysis projects of this P41, as it supplies a quantitative spatial reference system in which brain data from multiple subjects and modalities can be compared and correlated.