OTHER FUNCTIONS TOPIC 267, MULTIFUNCTIONAL THERAPEUTICS USING ENGINEERED PLANT V

“生物纳米粒子”是这一提议的基础。植物病毒纳米颗粒（PVN）基于一种存在于人类食物链中的病毒；无毒，免疫原性低；可以通过简单的过程将医学显像剂和/或治疗药物装载到其“货物舱”中；并且可以被设计用于识别和进入癌细胞，并在细胞结构内释放药物有效载荷，例如大多数抗癌药物起作用的细胞核，绕过大多数癌细胞防御。它有一个高度进化的传感器/执行器系统，只在目标细胞中释放货物。在这个二期项目中，NanoVector, Inc.将：使用人类黑色素瘤异种移植进行小鼠药理学研究和疗效研究；提高PVN生产效率和可扩展性；通过生物分布和生物消除数据进行长期毒性研究，以及早期IND研究，并启动大型动物研究。

A ¿biologic nanoparticle¿ is the basis of this proposal. The plant virus nanoparticle (PVN) is based on a virus that: exists in the human food chain; is nontoxic and of low immunogenicity; can load medical imaging agents and/or therapeutic drugs into its ¿cargo chamber¿ by a simple process; and can be engineered to identify and enter cancer cells and release drug payloads inside cell structures, such as the nucleus where most anticancer drugs operate, bypassing most cancer cell defenses. It has a highly evolved sensor/actuator system to release cargo only in the targeted cell. In this Phase II project, NanoVector, Inc. will: perform mouse pharmacology studies and efficacy studies using human melanoma xenografts; increase PVN production efficiency and scalability; perform long term toxicity studies with biodistribution and bioelimination data, as well as early IND enabling studies, and initiation of large animal studies.