UCLA Center for AIDS Research (CFAR)

描述（由申请人提供）：本申请是加州大学洛杉矶分校（UCLA）艾滋病研究中心（CFAR）资助的续期申请。这笔赠款将用于资助加州大学洛杉矶分校艾滋病研究所内的加州大学洛杉矶分校艾滋病防治中心开展的活动和项目。加州大学洛杉矶分校艾滋病研究中心于1988年成立，艾滋病研究所于1992年成立，以协调大学及其七所附属教学医院在一个中央管理下的所有艾滋病研究、临床和教育活动。艾滋病研究所和CFAR的整体组织在2005年进行了重组，以便更有效地管理在过去五年中增长了30%的师资队伍和自上次提交续期申请以来增长了50%的CFAR资助。此更新应用程序包括CFAR的核心服务和活动，旨在通过基础科学、临床科学和行为科学促进对艾滋病毒/艾滋病的了解。加州大学洛杉矶分校CFAR的总体使命是在不同学科之间建立协同效应，从而在艾滋病毒感染的理解、预防和治疗方面取得重大突破——特别强调高价值的跨学科合作。加州大学洛杉矶分校CFAR由200多名教员组成，他们负责250多个研究项目，涵盖了艾滋病毒/艾滋病生物学、临床研究和行为科学的几乎所有方面。加州大学洛杉矶分校在艾滋病研究、教育和教学以及临床项目方面一直名列前茅。洛杉矶大都会是艾滋病流行的主要中心，也是美国文化最多样化的地区之一，我们的项目旨在接触到这些不同的社区。我们特别自豪的是，近年来在我们临床试验中招募的患者中有50%是少数民族社区的成员。CFAR的作用是通过支持科学和行政核心设施，以及为有价值的合作研究项目提供种子基金，促进大学内外的合作和建立联系。申请支持的第一年（2008年1月至2008年12月）的行动计划总结如下：CFAR计划继续支持先前CFAR拨款资助的8个核心：行政核心、发育核心、病毒学/BSL3组织培养核心、细胞计数核心、小鼠/人类嵌合核心、基因和细胞治疗核心、粘膜免疫学核心和生物统计学核心。根据不断变化的流行病学、需求评估、战略规划和修订的短期和长期目标，取消了两个核心，增加了一个临床研究促进核心和一个咨询核心。

DESCRIPTION (provided by applicant): This application constitutes a renewal on the part of the University of California/Los Angeles (UCLA) for a Center for AIDS Research (CFAR) grant. This grant will fund activities and programs conducted by the UCLA CFAR within the UCLA AIDS Institute. The UCLA CFAR was set up in 1988, and the AIDS Institute was established in 1992 to coordinate all AIDS research, clinical and educational activities at the University and its seven affiliated teaching hospitals under one central administration. The overall organization of the AIDS Institute and the CFAR was restructured in 2005, in order to more efficiently and effectively manage a faculty that has grown by 30% in the last five years and CFAR-applicable grants that have risen by 50% since we submitted our last renewal application. This renewal application includes CFAR core services and activities that are designed to advance knowledge of HIV/AIDS through the basic, clinical, and behavioral sciences. The overall mission of the UCLA CFAR is to create synergies among diverse disciplines that result in significant breakthroughs in the understanding, prevention and treatment of HIV infection-with particular emphasis on high-value cross-disciplinary collaborations. The UCLA CFAR consists of more than 200 faculty investigators who are responsible for more than 250 research projects that encompass virtually all aspects of HIV/AIDS biology, clinical studies, and behavioral science. UCLA has consistently been ranked among the top institutions for excellence in AIDS research, education and teaching, and clinical programs. Metropolitan Los Angeles is a major epicenter for the AIDS epidemic and one of the most culturally diverse regions in the nation, and our programs are designed to reach out to these diverse communities. We are particularly proud that 50% of the patients recruited into our clinical trials in recent years are members of minority communities. The role of the CFAR is to foster collaboration and build linkages both within and outside the university, through support of scientific and administrative core facilities, and the provision of seed grant funding for highly meritorious collaborative research projects. The action plan for the first year of requested support, January 2008 to December 2008, is summarized as follows: The CFAR plans to continue supporting eight of the cores funded by the previous CFAR grant: Administrative Core, Developmental Core, Virology/BSL3 Tissue Culture Core, Cytometry Core, Mouse/Human Chimera Core, Gene and Cellular Therapy Core, Mucosal Immunology Core, and the Biostatistics Core. Based upon changing epidemiology, needs assessments, strategic planning and revised short- and long-term goals, two cores were eliminated and a Clinical Research Facilitation Core and a Consultation Core are added. CORE A: Administrative Core (Zack, J.) CORE A DESCRIPTION (provided by applicant): The Administrative Core of the UCLA CFAR will provide infrastructure support that adds value to all AIDS-related research and programs at UCLA. The Administrative Core is responsible for overseeing all operational and governance aspects of the UCLA CFAR. The joint administration of the UCLA CFAR and the AIDS Institute provides the following forms of support for the CFAR: fiscal administration and grants management, procurement of equipment and supplies, short- and long-range planning, administrative support for CFAR symposia, colloquia, and think tanks (including financial, editorial, graphic-design, and logistical support), development of educational programs for scientists and laypersons, on-campus and community-based outreach activities, administrative support for seed grant and fellowship reviews, compliance with all UCLA, University of California and NIH requirements, marketing and fund-raising, respond to requests for information and assistance (from the NIH, from our colleagues and collaborators, from the press and public), and supervision of all of the day-to-day activities of the CFAR. The Administrative Core will provide efficient, effective management of all CFAR programs through an accessible, streamlined and responsive administrative operation. The Administrative Core is overseen jointly by the Principal Investigator of the CFAR, Dr. Jerome Zack, and the Co-Pi of the CFAR, Dr. In/in Chen, who is also the Director of the UCLA AIDS Institute. The specific aims of this Core are: Aim 1. Program Development: Develop, implement and coordinate programs that support the wide-ranging research activities of the UCLA CFAR through a flexible and responsive administrative structure designed to maximize access to information and assistance, to enhance communication and to encourage collaboration. Aim 2. New Investigator Development: Facilitate the work of all UCLA AIDS researchers, but particularly junior, new and minority investigators, through specific mechanisms, such as mentorship programs and assistance with IRB applications, human-subject recruitment, data analysis, and grant writing, that reduce time, costs, and effort. Aim 3. Business Affairs Administration: To provide an infrastructure dedicated to AIDS research through funding of administrative services and overall coordination of research activities, think tanks, seed grant reviews and other activities of the CFAR.