Nutrition/Weight Loss, Exercise, Wellness Treatment for Bipolar Disorder

描述（由申请人提供）：心血管疾病（CVD）是双相情感障碍发病率和死亡率的主要原因，但没有经验验证的社会心理干预措施来管理双相情感障碍中CVD的危险因素。这项以指导患者为导向的研究职业发展奖的目的是开发和测试降低心血管疾病风险因素的综合治疗的可行性和可接受性，同时试验其疗效。设计的治疗整合了营养/减肥策略、运动干预和健康（NEW Tx）的理论，以解决心血管疾病与双相情感障碍共同发生的危险因素。NEW Tx包括这三个模块中的每一个新的干预策略，以及修改和定制的经验支持的双相情感障碍策略。主要假设是，NEW Tx将是可行的，可接受的人群，并与心血管疾病风险因素（即Framingham风险评分）的改善相关超过20周。探索性分析将检验治疗反应的预测因素以及NEW Tx对情绪症状和整体功能的影响。培训将在以下方面进行：1)手册开发和临床试验；2)饮食和运动干预及评估；3)完善的临床试验纵向数据分析统计模型。培训和研究计划支持候选人的长期目标，即建立一个创新的多学科项目，个性化治疗研究，针对双相情感障碍中心血管疾病不成比例的医疗负担，这是一个重要的公共卫生问题。该领域的进一步研究有可能改善双相情感障碍患者的生活，减少他们的医疗入院率和治疗和管理共病心血管疾病的遭遇。

DESCRIPTION (provided by applicant): Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in bipolar disorder, yet no empirically validated psychosocial interventions to manage risk factors for CVD in BD have been developed. The purpose of this Mentored Patient-Oriented Research Career Development Award is to develop and test the feasibility and acceptability of an integrated treatment to decrease CVD risk factors, while piloting its efficacy. The designed treatment integrates theories on Nutrition/weight loss strategies, Exercise interventions, and Wellness (NEW Tx) to address risk factors for CVD that co-occur with bipolar disorder. NEW Tx includes novel intervention strategies in each of these three modules, as well as modified and tailored empirically-supported strategies for bipolar disorder. The primary hypotheses are that NEW Tx will be feasible to deliver, acceptable to this population, and associated with improvements in CVD risk factors (i.e., Framingham Risk Score) over 20 weeks. Exploratory analyses will examine predictors of treatment response and the effect of NEW Tx on mood symptoms and overall functioning. Training will be sought in: 1) manual development and clinical trials; 2) diet and exercise interventions and assessment; and 3) sophisticated statistical models for longitudinal data analysis of clinical trials. The training and research plan supports the candidate's long-term goal of establishing a multidisciplinary program of innovative, personalized treatment research that targets the disproportionate medical burden of CVD in bipolar disorder, an important public health problem. Further research in this area has the potential to improve the lives of individuals with bipolar disorder, by reducing their medical admissions and encounters for treatment and management of comorbid CVD.