Allergy and Clinical Immunology Training Grant

描述（由申请人提供）：此申请是为了继续支持过敏和临床免疫学培训计划，该计划是为博士后医学和儿科学员设计的。有一个双重培训教员。首先，来自儿科、过敏和临床免疫学、风湿病学、肺病、胃肠病学、皮肤病学、传染病学和人类转化免疫学等医学部门的临床医生和研究人员。其次是导师，他们主要是来自耶鲁大学优秀的免疫生物系的基础科学家。他们的专业知识几乎涵盖了过敏、临床免疫学和现代免疫学的所有重要领域；包括：体液、细胞、分子、遗传、生化、抗原加工/呈递和信号研究。有些教员是莱姆病方面的专家，莱姆病是耶鲁的教员在这个培训项目中发现的。我们继续对蜱虫进行siRNA治疗，以了解发病机制并开发疫苗。在过敏学和临床免疫学方面有严格的培训，在风湿病学、皮肤病学、胃肠病学、肺病学和耳鼻喉科的免疫学方面也有一些培训。培训师资配备齐全的主要仪器，包括：优秀的流式细胞仪，寡核苷酸合成器，蛋白质测序仪和阵列和深度cDNA测序（Illumina/Solexa）。这是一个小型的高质量培训项目，每年只招收一名新研究员，有一个庞大的教师队伍，强调至少需要3-5年的实验室研究，为研究医学的职位做好准备，这是我们关注的重点。教师有很强的培训记录和合作研究互动。研究员第一年在临床活动中度过。第二年和第三年完全在免疫生物学教师导师的指导下进行研究项目，同时参加各种免疫生物学和临床科学课程，参加每周的研讨会和期刊俱乐部，并定期就他们的研究和感兴趣的免疫/过敏主题进行演讲。总之，该项目为未来医学和儿科学术职位的优秀候选人提供了独特且非常高质量的培训，并且在30多年的持续资助下在这方面取得了相当大的成功。

DESCRIPTION (provided by applicant): This application is for the continued support of a training program in Allergy and Clinical Immunology that is designed for postdoctoral medical and pediatric trainees. There is a double training faculty. Firstly, clinician-researchers from Pediatrics, the Department of Medicine in Allergy and Clinical Immunology, Rheumatology, Pulmonary, Gastroenterology, Dermatology, Infectious Diseases and Human Translational Immunology. Secondly, Mentors, who are basic scientists mainly from Yale's outstanding Department of Immunobiology faculty. Together, their expertise spans nearly all of the areas important to allergy, clinical immunology, and modern immunology; including: humoral, cellular, molecular, genetic, biochemical, antigen- processing/presenting, and signaling research. Some faculty are experts in Lyme disease, which was discovered at Yale by faculty in this training program. We continue with siRNA treatment of ticks to understand pathogenesis and develop vaccines. There is rigorous training in Allergy, and Clinical immunology, and some in Immunologic aspects of Rheumatology, Dermatology, Gastroenterology, Pulmonary, and ENT. The training faculty is well equipped with major instruments including: outstanding flow cytometry, oligonucleotide synthesizer, protein sequinator and access to array and deep cDNA sequencing (Illumina/Solexa). This is a small high quality training program, taking only one new fellow per year, with a large faculty emphasizing the need for at least of 3-5 years of laboratory research to prepare trainees for positions in research medicine, upon which we are focused. The faculty have a strong training record and collaborative research interactions. The fellows spend their first year in clinical activities. The second and third years entirely in a research project under an Immunobiology faculty mentor, while taking various immunobiology and clinical science courses, participating in weekly seminars and journal clubs, and regularly giving talks on their research, and immunologic/allergy subjects of interest. In summary, the program offers unique and very high quality training of outstanding candidates for future positions in academic medicine and pediatrics, and has been quite successful in this regard over more than 30 years of continuous funding.