Mucosal biology scientific research support component

这个粘膜生物学科学研究支持部分(SRSC)的主要目标是确定防止HIV-1感染所需的粘膜表面抗体效应器功能，确定它们在传播途径上的差异，并通过跨SRSC(粘膜、媒介、非人灵长类)的综合研究确定在非人类灵长类动物和协作人类临床疫苗研究中保护性抗体诱导的模式。 具体目标 目的1.通过确定在RV144后续试验(RV306，RV328)、其他HLV-1疫苗试验(HVTN 204,082,076)和HVTN/CHAVI501马赛克试验中引起的粘膜表面保护性抗体反应的功能性质来支持CHAVI-ID。 目的2.通过评估NHP核心研究中粘膜表面保护性抗体的功能特征来支持CHAVI-ID，该研究旨在确定诱导粘膜免疫的最佳路线/佐剂组合。 目的3.在NHP和载体SRSC研究中，通过评估粘膜表面保护性抗体的功能特征来支持CHAVI-ID，旨在确定诱导粘膜免疫的最佳载体策略。 目的4.通过确定二聚体抗体与单体抗体对粘膜获取的影响来支持CHAVI-ID。

The primary goal of this Mucosal Biology Scientific Research Support Component (SRSC) is to identify antibody effector functions at mucosal surfaces required to prevent HIV-1 acquisition, define how they differ by route of transmission, and through integrated studies across SRSCs (Mucosal, Vector, Non-human Primate) determine modes of protective antibody induction in non-human primates and in collaborative human clinical vaccine studies. Specific Aims Aim 1. To support CHAVI-ID by defining the functional nature of protective antibody responses at mucosal surfaces elicited in RV144 follow-on trials (RV306, RV328), in other HlV-1 vaccine trials (HVTN 204, 082, 076) and in the HVTN/CHAVI501 mosaic trial. Aim 2. To support CHAVI-ID by assessing the functional characteristics of protective antibodies at mucosal surfaces in NHP Core studies designed to determine optimal route/adjuvant combinations for the induction of mucosal immunity. Aim 3. To support CHAVI-ID by evaluating the functional characteristics of protective antibodies at mucosal surfaces in NHP and Vector SRSC studies designed to determine optimal vector strategies for the induction of mucosal immunity. Aim 4. To support CHAVI-ID by determining the impact of dimeric vs monomeric antibodies on mucosal acquisition.