Building social networks to achieve healthy weight gain during pregnancy

描述(由申请人提供)：拟议的研究和培训计划的目标是发展一项专注于预防儿童肥胖的独立转化性研究事业。Sabina Gesell博士的长期职业目标是在社会网络及其在传播健康行为方面的效用方面建立专业知识，目的是开发基于人群的干预措施，以(1)针对与晚年肥胖有关的人类发展的关键窗口，(2)可持续的。制度环境和对候选人的承诺是理想的：儿科系主任、儿科研究事务副主席和儿科学院发展副主席都坚定地致力于她的成功，并提供必要的保护时间和方向，以实现本提案中列出的目标。作为分部主任和首席导师，Shari Barkin博士致力于通过指导和资源来积极支持她，以确保项目成功和职业发展成为一名富有成效的独立研究人员。范德比尔特开发成功的T2研究项目的CTSA基础设施是无与伦比的。拟议的职业发展计划侧重于通过(1)严格执行研究计划、(2)密集的研究指导、(3)高级课程作业、(4)独立学习、(5)教员研究研讨会和工作组以及(6)国家会议，获得社会网络分析、现代纵向数据分析技术、成本效益分析以及社区参与研究的伦理和方法方面的知识和高级技能。相关的研究项目是一个社交网络干预，旨在促进怀孕期间健康的体重增加。据估计，45%的美国女性在怀孕期间体重增加超过了医学研究所(IOM)的临床指导方针。妊娠期体重过度增加与妊娠期糖尿病、妊娠高血压、分娩和分娩并发症、婴儿巨大儿、儿童肥胖症和产后持续性母体肥胖症有关。国际移民组织和医疗保健研究和质量机构(AHRQ)都认为，缺乏有效的孕期体重增加干预措施是一个主要的研究空白。拟议研究项目的目标是(1)完善为拉丁裔妇女量身定做的社会网络干预措施，以防止怀孕期间体重过度增加；(2)对120多名怀孕的拉丁裔妇女(E16岁)进行随机对照试验，以测试这种以社区为基础的干预措施对妊娠体重增加的影响和在IOM目标范围内增加的可能性；以及(3)检查怀孕期间健康的生活方式(营养、体育活动)通过新的社会关系传播的程度。这项研究将建立在这个研究小组已经建立的信任和实质性社区关系的基础上，以及他们支持拟议方法的广泛的初步研究。培训和研究将支持成功的R01。

DESCRIPTION (provided by applicant): The objective of the proposed research and training plan is to develop an independent translational research career focused on the prevention of pediatric obesity. Dr. Sabina Gesell's long-term career goal is to build an expertise in the measurement of social networks and their utility in spreading health behaviors with the purpose of developing population-based interventions that (1) target critical windows of human development associated with obesity later in life, and (2) are sustainable. The institutional environment and commitment to the candidate are ideal: Department Chair, Vice Chair for Research Affairs in Pediatrics, and Vice Chair for Faculty Development in Pediatrics are all firmly committed to her success and providing the necessary protected time and direction to attain the goals outlined in this proposal. Division Director and Primary Mentor, Dr. Shari Barkin has committed to actively supporting her through mentoring and resources to ensure project success and career development into a productive independent researcher. Vanderbilt's CTSA infrastructure to develop a successful T2 research program is unparalleled. The proposed career development plan is focused on gaining knowledge and advanced skills in social network analysis, modern longitudinal data analytic techniques, cost-effectiveness analyses, and ethics and methods of community-engaged research through (1) rigorous conduct of the research plan, (2) intensive research mentorship, (3) advanced coursework, (4) independent study, (5) faculty research seminars and working groups, and (6) national meetings. The associated research project is a social network intervention designed to facilitate healthy weight gain during pregnancy. It is estimated that 45% of US women gain in excess of the Institute of Medicine (IOM) clinical guidelines for weight gain during pregnancy. Excessive gestational weight gain is associated with gestational diabetes mellitus, pregnancy-related hypertension, complications through labor and delivery, infant macrosomia, childhood obesity, and persistent maternal obesity postpartum. Both the IOM and the Agency for Healthcare Research and Quality (AHRQ) have identified the lack of effective gestational weight gain interventions as a major research gap. The goals of the proposed research project are (1) To refine a culturally-tailored social network intervention for Latina women to prevent excessive weight gain during pregnancy; (2) To conduct a randomized controlled trial with more than 120 pregnant Latinas (e16 years old) to test the effect of this community-based intervention on gestational weight gain and likelihood of gaining within IOM target ranges; and (3) To examine the extent to which healthy lifestyle behaviors during pregnancy (nutrition, physical activity) are spread through new social ties. The study will build on the trust and substantive community relationships already developed by this research team, as well as their extensive preliminary research that supports the proposed approach. The training and research will support a successful R01.