Spatial-Temporal Heterogneiety in Pulmonary Blood Flow

描述（由申请人提供）：这些研究的总体长期目标是了解控制肺血流量的机制，以及这种控制如何导致健康和疾病中的气体交换缺陷或优化。具体目标是使用一种新的MRI技术来量化正常人体肺部血液流动的时空动态。许多生理系统的时间异质性已被发现是健康功能的标志，但由于测量时间异质性的适当工具尚未可用，因此对人体肺部血流的时间动态知之甚少。最近，我们开发了一种非侵入性MRI技术，该技术提供了肺血流的定量测量，其空间分辨率为~1 cm3，时间分辨率为~10 s，使我们能够首次检查人体肺部的时空异质性。在这个项目的框架下，具体目标是：1)为研究员提供MRI技术发展方面的培训，目标是提高这些研究中的时间分辨率；2)开发创新的分析技术，包括非线性系统的各个方面，以表征我们的实验技术产生的丰富数据集；3)检查改变吸入气体（O2和CO2）对健康受试者的影响。

DESCRIPTION (provided by applicant): The overall long-term goal of these studies is to understand the mechanisms by which pulmonary blood flow is controlled, and how that control contributes to gas exchange defects or optimization in health and disease. The specific goal is to use a novel MRI technique to quantify the spatial and temporal dynamics of blood flow in the normal human lung. Temporal heterogeneity in a number of physiological systems has been found to be a mark of healthy function, yet little is known about the temporal dynamics of blood flow in the human lung because the appropriate tools for measuring temporal heterogeneity have not been available. Recently we developed a noninvasive MRI technique that provides quantitative measurements of pulmonary blood flow with a spatial resolution of ~1 cm3 and a temporal resolution of ~10 s in the human lung permitting us to examine spatial-temporal heterogeneity in the human lung for the first time. Under the umbrella of this project, the Specifi Aims are designed to: 1) provide the fellow with training in the development of MRI techniques, with a goal of improving the temporal resolution in these studies; 2) to develop innovative analysis techniques including aspects of non-linear systems to characterize the rich data sets resulting from our experimental techniques; and 3) examine the effects of altered inspired gas (O2 and CO2) in healthy subjects. PUBLIC HEALTH RELEVANCE: The overall long-term goal of these studies is to understand the mechanisms by which pulmonary blood flow is controlled, and how that control contributes to gas exchange defects or optimization in health and disease. The importance of how pulmonary blood flow is controlled over time has never been studied in humans because of a lack of suitable tools. This project will study the temporal behavior of the distribution of pulmonary blood flow in humans for the first time laying the foundations for addressing future treatment of gas exchange defects.