Training in Congenital & Acquired Heart Disease

描述(由申请人提供)： 俄亥俄州立大学(OSU)和国立儿童医院(NCH)机构T32博士后项目的目标是在先天性和获得性心脏病方面提供跨学科、翻译和最先进的研究培训。这一计划提供了一个独特的机会来关注从出生到衰老的先天性和获得性心脏病的连续体，并比较这些不同人群之间的疾病机制和结果。其基本原理是，心脏病治疗和预防方面的进步最有可能源于一项转化性研究计划，该计划促进了医生科学家和基础科学家之间的合作。为了解决总体主题，我们将保持和扩大正在进行的努力，以提供一个学术环境，以培养真正的‘双向’转化研究，以便我们的临床科学家发现的重大临床问题可以在实验室得到解决，而工作台上的关键发现可以迅速转化为更大的动物研究，并最终回到床边。 这项新申请每年招聘5名实习生，为期5年，为期2年。研究员将从对心血管研究有浓厚兴趣并致力于以疾病为导向的研究的MD、DVM或博士候选人中挑选。项目主任在转化性心血管研究方面有着良好的记录，并将担任各自机构的主要主任。培训计划设计包括正式的学术课程、研讨会和期刊俱乐部，为学员提供心脏病概述和深入的心脏研究方向。学员将参加一个量身定做的“生存技能”课程，其中包括与专业发展有关的各种单元和工作坊。每个学员将在导师的实验室进行独立的研究项目。研究领域由20名由外部资助的基础和临床科学导师和22名参与的教职员工代表，他们分别与国立卫生研究院的心脏中心和俄亥俄州立大学的戴维斯心肺研究所有联系。将使用一个基于网络的跨机构系统来进行实习生和导师评估。

DESCRIPTION (provided by applicant): The objective of this joint Ohio State University (OSU)-Nationwide Children's Hospital (NCH) institutional T32 postdoctoral program is to provide interdisciplinary, translational and state-of-the-art research training in congenital and acquired heart disease. This plan provides a unique opportunity to focus on a continuum of congenital and acquired heart disease from birth to senescence and to compare disease mechanisms and outcomes between these diverse population. The rationale is that advances in heart disease therapy and prevention are most likely to originate from a translational research program that fosters collaboration between physician-scientists and basic scientists. To address the overall theme, we will maintain and expand ongoing efforts to provide an academic environment to cultivate true 'bidirectional' translational research, so that significant clinical problems identified by our clinician scientists can be addressed in the laboratory, and key findings at the bench can be rapidly translated to larger animal studies and eventually back to the bedside. This new application seeks 5 trainees per year for 5 years with a 2-year commitment. Fellows will be selected from MD, DVM or PhD candidates who have strong interests in cardiovascular research and are committed to careers in disease-oriented investigations. The Program Directors have a strong-track record in translational cardiovascular research and will serve as the primary directors at their respective institutions. The training plan design consists of formal academic courses, seminars and journal clubs to provide trainees with an overview of heart disease and an in-depth cardiac research orientation. Trainees will participate in a tailor-made "survival skills" course comprised of various modules and workshops related to professional development. Each trainee will perform independent research projects in a mentor's laboratory. The research areas encompassed by the 20 extramurally funded basic- and clinical-science mentors and 22 participating faculty are represented by their individual affiliations with The Heart Center at NCH and The Davis Heart and Lung Institute at OSU. A cross-institution, web-based system will be used to perform trainee and mentor evaluations.