Lipids in Cardiac Health and Disease: From Toxicity to Protection

描述（由申请人提供）：本次会议的目标是介绍和讨论脂质在心脏生理学和病理学中的作用的最新信息，重点是跨学科的相互作用和思想和科学方法的多样性。越来越多的证据表明，美国心血管疾病的高发病率主要是由于不良的饮食选择和肥胖。此外，现在已经确定，膳食脂质通过改变底物代谢、膜磷脂、基因表达的激活以及脂质介质引起的细胞信号传导的变化来影响心脏功能和结构。高摄入选择性脂肪酸可获得临床益处，而特定脂质化合物可产生心脏毒性作用。这些问题通过在很大程度上独立于血管系统的机制影响心脏病的发展和进展。我们将在2013年9月29日至10月2日于马里兰州剑桥举行的第11届心脏和血管代谢学会年会上全面讨论这些重要主题，该年会题为“心脏健康和疾病中的脂质：从毒性到保护”。会议的目标是为与会者提供以下方面的最新信息：1）膳食脂质对心脏功能、结构和疾病发生的影响，2）心脏磷脂组成对代谢和收缩功能的影响，3）评估信号传导、代谢和膜磷脂的脂质组学方法，4）异位脂质储存的机制（脂滴形成、调节和功能），5）肥胖、2型糖尿病、缺血和心力衰竭对心脏脂质代谢的影响，6）脂质代谢的药理学和饮食操纵以获得最佳心脏健康。这种会议形式将促进受训人员与初级调查员和资深调查员之间的互动。 该计划包括23名特邀发言人，来自早期调查人员，妇女和代表性不足的少数民族的代表。提交的摘要将以15分钟的演讲和海报形式呈现。对于学员将有一个特色的会议，包括论文研究的简短快速口头陈述。会议的论文将发表在《美国生理学杂志-心脏循环生理学》的一系列精选评论论文中。请拨资金用于：i）早期研究人员的注册和住宿费用，ii）资助学员的注册费，iii）为被选中进行口头摘要介绍的学员提供4次旅行奖励，以及iv）租用海报板。

DESCRIPTION (provided by applicant): The goal of this conference is to present and discuss the latest information on the role of lipids in cardiac physiology and pathology, with emphasis on interdisciplinary interaction and diversity of ideas and scientific approaches. There is growing evidence that much of the high incidence of cardiovascular disease in the US is due to poor dietary choices and obesity. Further, it is now established that dietary lipids effect cardiac function and structure through alterations in substrate metabolism, membrane phospholipids, activation of gene expression, and changes in cell signaling by lipid mediators. Clinical benefit i seen with high intake of select fatty acids, while specific lipid compounds exert cardiotoxic effects. These issues impact the development and progression of heart disease through mechanisms that are largely independent of the vasculature. We will fully address these important topic at the 11th Annual Meeting of the Society for Heart and Vascular Metabolism, entitled "Lipids in Cardiac Health and Disease: From Toxicity to Protection", September 29 - October 2, 2013 in Cambridge, MD. The goals of the conference are to provide attendees with the latest information on: 1) Effects of dietary lipids on cardiac function, structure and incidenc of disease, 2) Impact of cardiac phospholipid composition on metabolic and contractile function, 3) Lipidomic approaches to assess signaling, metabolism and membrane phospholipids, 4) Mechanisms of ectopic lipid storage (lipid droplets formation, regulation, and function), 5) Effects of obesity, type 2 diabetes, ischemia and heart failure on cardiac lipid metabolism, 6) Pharmacological and dietary manipulation of lipid metabolism for optimal cardiac health. The meeting format will facilitate interaction among trainees and junior and established investigators. The program includes 23 invited speakers, with representation from early stage investigators, women, and underrepresented minorities. Submitted abstracts will be presented as 15 min talks and posters. For trainees there will a featured session comprised of short rapid oral presentations of dissertation research. The proceeding from the conference will be published in the Am J Physiol-Heart Circ Physiol in series of featured review papers. Funds are requested for: i) registration and housing expenses of early stage investigators, ii) subsidizing the registration fee of trainees, iii) 4 travel awards from trainees selected for oral abstract presentation, and iv) rental of poster boards.