2012 Tetrapyrroles GRC

描述(由申请者提供)：自1966年以来，四吡咯的化学和生物学戈登会议一直试图将来自不同学科的个人聚集在一起，探索四吡咯颜料在所有生命王国中的作用。临床医生、动植物生物学家、微生物学家、化学家、生物物理学家和生物工程师齐聚一堂，讨论和分享以四种角色为共同主题的研究兴趣。因此，在术语流行之前，这次会议一直站在鼓励“跨学科”和“翻译”研究的前沿。在四吡咯化学与生物学GRC中，没有其他具有广泛研究学科传统的四吡咯研究界的会议。2012年四种角色的化学和生物学戈登研究会议的具体目标是：1.为对四吡咯分子的化学和生物学有共同兴趣的基础和临床科学家之间讨论尖端未发表的研究提供一个论坛，以及2.)通过在正式陈述后提供充足的讨论时间，通过举行海报会议作为讨论共同利益的焦点，并通过培养促进翻译研究合作的大学氛围，将来自各种科学学科的现有研究人员和新的研究人员聚集在一起，促进与临床同行的思想交流。每一次会议都被安排成包括一系列学科，同时侧重于一个特定的研究领域。例如，关于疾病状态下的四吡咯的会议将涵盖哺乳动物和模式生物中红系发育的分子和生理方面，卟啉症和X连锁铁粒母细胞贫血的生化基础和临床疾病状态，以及寄生虫感染期间血红素的获取和利用。演讲者包括各自学科的知名研究人员，以提供知名度，以吸引该领域最优秀的研究人员出席，以及年轻的研究人员 世卫组织将为会议带来新鲜和创新的想法。整个会议将突出年轻研究人员的重要工作，并鼓励与会者与该领域的新手进行互动和交流。 公共卫生相关性：拟议的会议与公共卫生相关，因为它汇集了不同的研究人员，他们的演讲将涵盖人类健康的各个方面，从血红素在细菌和寄生虫感染中的作用，到血红素合成的遗传性障碍，特别是与红细胞生成有关的疾病。四吡咯的化学和生物学GRC会议与NIH的使命相关，因为它响应了支持活动的目标，这些活动将导致对国家保护和改善健康的进步至关重要的新发现。

DESCRIPTION (provided by applicant): Since 1966 The Chemistry & Biology of Tetrapyrroles Gordon Conference has sought to bring together individuals from diverse disciplines to explore the role of tetrapyrrole pigments across all kingdoms of life. Clinicians, plant and animal biologists, microbiologists, chemists, biophysicists, and bioengineers meet to discuss and share research interests that have tetrapyrroles as the common theme. Thus, this conference has been at the forefront of encouraging "interdisciplinary" and "translational" research before the terms were popular. There is no other meeting of the tetrapyrrole research community with a similar tradition of broad research disciplines as is found in the Chemistry & Biology of Tetrapyrroles GRC. The specific aims of the 2012 Chemistry and Biology of Tetrapyrroles Gordon Research Conference are: 1.) to provide a forum for the discussion of cutting edge unpublished research between basic and clinical scientists who have a common interest in the chemistry and biology of tetrapyrrole molecules, and 2.) to bring together and promote the exchange of ideas between established and new investigators from a wide variety of scientific disciplines with their clinical counterparts by providing ample discussion time following formal presentations, by holding poster sessions that serve as a focus for the discussion of common interests, and by fostering a collegial atmosphere that promotes translational research collaborations. Each session has been organized to include a spectrum of disciplines while focusing on a specific area of research. For example, the session on tetrapyrroles in disease states will cover the molecular and physiological aspects of erythroid development in mammals and model organisms, the biochemical basis and clinical disease states of porphyrias and X-linked sideroblastic anemia, and heme acquisition and utilization during parasitic infections. Speakers include established researchers in their respective disciplines to provide the name recognition to attract the attendance of the best researchers in the field, and young investigators who will bring fresh and innovative ideas to the meeting. Significant work by young investigators will be highlighted throughout the conference and attendees are encouraged to interact and confer with those new to the field. PUBLIC HEALTH RELEVANCE: The proposed conference is relevant to public health since it brings together diverse researchers whose presentations will cover aspects of human health ranging from the role of heme in bacterial and parasitic infections to genetic disorders of heme synthesis, especially those related to erythropoiesis. The Chemistry and Biology of tetrapyrroles GRC conference is relevant to the Mission of NIH since it responds to the goal to support activities that will lead to new discoveries that are basic to the advancement of the Nation to protect and improve health.