Comparative Oncology

加州大学戴维斯分校癌症中心的比较肿瘤学项目专注于动物癌症生物学的几个特定方面。第一个主题是肿瘤生物学，主要研究癌基因和抑癌基因.癌症干细胞和炎症-癌症。第二大主题。肿瘤的基因定义动物模型是采用转基因和基因敲除动物模型来阐明肿瘤发生和发展的基本机制的研究。第三个主题是大型动物的自发性癌症，使用非啮齿动物研究肿瘤的发展，并在临床前环境中研究新的诊断和治疗方法。该计划为临床前环境带来了独特的技能和模型组合。它提供了工作台和床边之间的关键联系。方案目标是：（1）使用体外系统和体内癌症的遗传定义的动物模型来检查癌基因和肿瘤抑制基因的信号传导途径以及炎症和癌症干细胞在肿瘤发生中的作用;（2）表征动物模型中的遗传诱导的肿瘤发生以及新的动物模型和实验方法的开发;（3）描述大型动物自发性癌症的特征，并对新的诊断和治疗方法进行临床前评估;（4）与其他项目合作，促进转化研究。该计划有来自加州大学戴维斯分校10个不同部门和3所学校的29名成员。它有17个NCI资助的项目，ADC为260万美元（同行评审的资金总额为1140万美元ADC）。在上一个供资期，该小组有524份出版物; 21%是方案间的，10%是方案内的。

The Comparative Oncology Program of the University of California, Davis Cancer Center focuses on several specific aspects of cancer biology in animals. The first major theme, Tumor Biology, is the study of major Oncogenes, Tumor Suppressor genes. Cancer Stem Cells and Inflammation-Cancer. The second major theme. Genetically Defined Animal Models of Cancer, is the study of tumor development and progression employing transgenic and knockout animal models to elucidate basic mechanisms. The third major theme, Spontaneous Cancers in Large Animals, uses non-rodent animals to study tumor development and investigate novel diagnostics and therapeutics in a preclinical setting. This program brings a unique combination of skills and models to the preclinical setting. It provides the critical links between bench and bedside. The programmatic goals are: (1) to examine the signaling pathways of oncogenes and tumor suppressor genes and the role of inflammation and cancer stem cells in tumorigenesis using both in vitro systems and genetically defined animal models of cancer in vivo; (2) to characterize genetically induced tumorigenesis in animal models and development of novel animal models and experimental approaches; (3) to characterize spontaneous cancers in large animals and to perform preclinical evaluation of novel diagnostics and therapeutics; and (4) collaboration with other programs to facilitate translational research. The program has 29 members from ten different departments and three schools at UC Davis. It has 17 NCl funded projects for $2.6 million ADC (total peer-reviewed funding, $11.4 million ADC). The group has 524 publications for the last funding period; 21% are inter-programmatic and 10% are intra-programmatic.