Assigning function to Acinetobacter baumanii sRNAs

鲍曼不动杆菌是一种新出现的病原菌，在医院感染中占很大比例。 感染。它也给伊拉克和阿富汗的军队带来了问题，在那里它是软组织的原因 与战争相关的创伤相关感染。鲍曼A.baumannii Xhaf的两个性质有助于其 作为病原体的持久性是它积累耐药基因的倾向和惊人的能力 容忍杀生剂和干燥剂。该项目将使用rna-seq分析来确定和定义功能。 其表达与7个临床相关的抗病性状相关 鲍曼曲霉(A.baumannii)这些问题包括对四种抗生素、两种杀菌剂和干燥剂的耐药性。SRNA是 它们是对特定环境信号的反应，它们被迅速合成，并迅速采取行动 在翻译水平上控制基因表达。我们假设sRNA有助于鲍曼不动杆菌的应对。 与抗生素、杀生剂和干燥暴露相关的细胞膜和新陈代谢压力。我们的 这一结果将为开发预防不动杆菌感染的新防线开辟道路。

Acinetobacter baumannii is an emerging pathogen responsible for a significant percentage of nosocomial infections. It has also been problematic for the military in Iraq and Afghanistan, where it is the cause of softtissue infections associated with war-related trauma. Two properties of A. baumannii Xhaf contribute to its persistence as a pathogen are its propensity to accumulate drug resistance genes and a striking ability to tolerate biocides and desiccation. This project will use RNA-seq analysis to identify and define the functions of sRNA regulators (sRNAs) whose expression is associated with seven clinically relevant resistance traits of A. baumannii. These include resistance to four antibiotics, two biocides and desiccation. sRNAs are expressed in response to specific environmental signals, they are synthesized rapidly and they act quickly to control gene expression at the translational level. We hypothesize that sRNAs help A. baumannii io cope with cell envelope and metabolic stresses associated with antibiotic, biocide and desiccation exposure. Our results will open avenues for the development of new lines of defense against Acinetobacter infections.