Effects of Yoga on CVD Risk Factors among African Americans: Jackson Heart Study

描述（由申请人提供）： 心血管疾病是美国死亡的主要原因，并且仍然是美国最大的种族健康差异状况之一：与非西班牙裔白人相比，非洲裔美国人死于心脏病的可能性高出30%，死于中风的可能性高出60%。非裔美国人也比白人更容易有心血管疾病的危险因素，如高血压和胆固醇，甘油三酯和HbA 1c水平升高。瑜伽对减轻心血管疾病风险因素的影响的临床研究，虽然性质很小，但已经证明了有希望的结果。该拟议研究采用随机、混合分阶段/交叉设计，包括来自杰克逊心脏研究的500名成年高血压或高血压前期非裔美国人参与者，以测试每周三次瑜伽课程持续12周对CVD风险因素的影响。该研究的三个具体目标是测量瑜伽对（1）CVD风险的影响，包括高血压，炎症，血脂和血红蛋白A1 c水平升高;（2）感知的压力水平;（3）健康行为和健康相关的生活质量。主要结果将是受试者收缩压和舒张压以及CRP、纤维蛋白原、同型半胱氨酸和白细胞介素-6水平的变化。次要结果将是参与者的HbA 1c，总胆固醇，LDL，HDL和空腹甘油三酯水平的变化;他们感知的压力水平;以及他们报告的健康行为和健康相关的生活质量。由于参与者的数量和研究设计的严谨性，这项研究将是同类研究中的第一项。研究小组有幸能够招募和留住大量的参与者，因为他们与杰克逊心脏研究的联合协会建立了长期和非常密切的关系。将向各种专业和非专业受众大规模传播成果。如果干预的结果在统计学上显著改善了个人的心血管疾病风险因素，那么国家将受益于一个易于复制的模型，该模型可用于帮助降低心血管疾病风险。

DESCRIPTION (provided by applicant): Cardiovascular disease is the leading cause of death in the U.S. and continues to be one of the nation's largest racial health disparity conditions: compared to non-Hispanic whites, African Americans are 30 percent more likely to die from heart disease and 60 percent more likely to die from a stroke. African Americans are also more likely than whites to have risk factors for CVD, such as hypertension and elevated levels of cholesterol, triglycerides, and HbA1c. Clinical studies of the effects of yoga on mitigating CVD risk factors, although small in nature, have demonstrated promising results. The proposed study, which utilizes a randomized, hybrid phase-in/cross- over design, includes 500 adult hypertensive or pre-hypertensive African American participants from the Jackson Heart Study to test the effect of yoga classes three times per week for 12 weeks on CVD risk factors. The three specific aims of the study are to measure the effect yoga can have on (1) risks for CVD, including hypertension, inflammation, and elevated levels of lipids and hemoglobin A1c; (2) perceived levels of stress; and (3) health behaviors and health-related quality of life. Primary outcomes will be changes in participants' systolic and diastolic blood pressure and their levels of CRP, fibrinogen, homocysteine, and interleukin-6. Secondary outcomes will be changes in participants' levels of HbA1c, total cholesterol, LDL, HDL, and fasting triglycerides; their perceived levels of stress; and their reported health behaviors and health-related quality of life. Because of the number of participants and the rigor of the research design, this study will be the first of its kind. The study team is in the fortunate position to be able to recruit and retain a large number of participants because of its longstanding-and remarkably close-relationship through their joint association with the Jackson Heart Study. Results will be disseminated on a large scale to a variety of professional and lay audiences. If the results of the intervention yield statistically significant improvement in individuals' CVD risk factors, the nation will benefit from an easily replicable model that can be used to help reduce CVD risk.