Spatial-Temporal Heterogneiety in Pulmonary Blood Flow

描述（由申请人提供）：这些研究的总体长期目标是了解控制肺血流的机制，以及该控制如何导致健康和疾病中的气体交换缺陷或优化。具体目标是使用一种新的MRI技术来量化正常人肺中血流的空间和时间动态。在许多生理系统中的时间异质性已被发现是健康功能的标志，但对人肺中血流的时间动力学知之甚少，因为用于测量时间异质性的适当工具还不可用。最近，我们开发了一种非侵入性MRI技术，提供定量测量的肺血流的空间分辨率为~1立方厘米和时间分辨率为~10秒，在人类肺部，使我们能够检查时空异质性在人类肺部的第一次。在该项目的保护伞下，Specifi的目的是：1）为研究员提供MRI技术开发方面的培训，目标是提高这些研究中的时间分辨率; 2）开发创新的分析技术，包括非线性系统的各个方面，以表征我们实验技术产生的丰富数据集;以及3）检查改变的吸入气体（O2和CO2）在健康受试者中的作用。

DESCRIPTION (provided by applicant): The overall long-term goal of these studies is to understand the mechanisms by which pulmonary blood flow is controlled, and how that control contributes to gas exchange defects or optimization in health and disease. The specific goal is to use a novel MRI technique to quantify the spatial and temporal dynamics of blood flow in the normal human lung. Temporal heterogeneity in a number of physiological systems has been found to be a mark of healthy function, yet little is known about the temporal dynamics of blood flow in the human lung because the appropriate tools for measuring temporal heterogeneity have not been available. Recently we developed a noninvasive MRI technique that provides quantitative measurements of pulmonary blood flow with a spatial resolution of ~1 cm3 and a temporal resolution of ~10 s in the human lung permitting us to examine spatial-temporal heterogeneity in the human lung for the first time. Under the umbrella of this project, the Specifi Aims are designed to: 1) provide the fellow with training in the development of MRI techniques, with a goal of improving the temporal resolution in these studies; 2) to develop innovative analysis techniques including aspects of non-linear systems to characterize the rich data sets resulting from our experimental techniques; and 3) examine the effects of altered inspired gas (O2 and CO2) in healthy subjects.