A Novel Adherence Technology for Ophthalmic Medications

摘要 支持慢性病患者药物管理的技术辅助工具正在激增， 电子远程医疗设备。药丸组织者、提醒者、监视器和使用通信器已经使一个 一系列家庭保健辅助工具，以支持使用者和护理人员进行药丸管理和监测。超越散装 药丸、附加的药物形式（例如局部药物）在独特的药物递送系统中越来越受欢迎。 然而，局部用药具有有限的用于促进和跟踪依从性的电子监测手段 尽管不遵守的后果和口服药物一样令人担忧。比如青光眼 是全球失明的主要原因，但患者对局部药物治疗方案的依从性 最好是次优的。眼科药物依从性由于以下几个独特的障碍而令人望而生畏：1）复杂性- 滴眼液的应用可能非常复杂，涉及每天多次服用多种药物，2） 给药-视力受损的患者通常无法正确识别药物和阅读标签，3） 不稳定性-许多药物对极端条件有不良反应，4）缺乏患者选择-没有多种药物 容器具有丰富的提醒、监控和干预功能。此外，一个主要 滴眼剂给药的障碍是实际上正确给药滴眼剂的问题。这 该项目将利用我们世界一流的药物依从性系统和我们团队的特殊技能， 在开发眼科药物分配系统方面的经验，该系统将指导、提醒、监控， 沟通，并在一个高度负担得起的，实用的和用户敏感的模型报告。它包括一滴 一种分配装置，确保只有一滴是正确适用于眼睛在无菌，安全和正确的， 红外监控应用。

ABSTRACT Technological aids supporting medication management for chronically ill patients are proliferating, offered in electronic telehealth devices. Pill organizers, reminders, monitors, and usage communicators have enabled an array of home health aids to support users and caregivers in pill management and monitoring. Beyond bulk pills, additional medication forms, such as topicals, are gaining popularity in unique drug delivery systems. However, topical medications have limited electronic monitoring means for promoting and tracking adherence even though the consequences of nonadherence are just as alarming as with oral meds. For example, glaucoma is a leading cause of blindness worldwide, yet patient compliance with topical medication regimens is suboptimal at best. Ophthalmic drug adherence is daunting due to several unique barriers: 1) complexity-- the application of eye drops can be highly complicated involving multiple drugs taken several times daily, 2) administration-- visually impaired patients often cannot correctly identify medication and read labels, 3) lability-- many drugs react adversely to extreme conditions, and 4) lack of patient options-- no multi-drug container exists with feature-rich reminding, monitoring, and intervention functions. Moreover, a primary barrier to administration of eye drops is the problematic issue of actually administering drops properly. This project will leverage our world-class medication adherence system and our team's exceptional skill sets and experience in developing an ophthalmic medication dispensing system that will instruct, remind, monitor, communicate, and report in a highly affordable, practical, and user-sensitive model. It includes a drop dispensing device that assures only one drop is properly applied to the eye in sterile, safe, and correct application with infrared monitoring.