Improving the use of chemotherapy by targeting the inflammatory response

患者在清除抗癌药物方面的差异对化疗的成功有重大影响。如果药物清除得太快，好处就会丧失，而清除得太慢会造成毒性。我们将使用具有良好特征的反映人类情况的小鼠模型来研究癌症药物新陈代谢降低的原因和影响。这些数据将指导未来的人体研究，从而改善诊断和治疗干预，以提高化疗的耐受性。

Patient differences in clearance of anti-cancer drugs have a major impact on the success of chemotherapy. Benefit is lost if the drug is cleared too rapidly, while slow elimination causes toxicity. We will use well characterised mouse models that mirror the human situation to study the causes and effects of reduced drug metabolism in cancer. The data will guide future human studies that will result in improved diagnostic and therapeutic interventions to improve the tolerance of chemotherapy.