"Interventions to Slow Aging in Humans: Are We Ready?"

描述（由申请人提供）：人类老龄化和年龄相关疾病正在成为发达国家和发展中国家面临的最大挑战之一。这些慢性疾病造成的经济负担已经是压倒性的，目前正在对发达国家的医疗保健和福利系统征税，但如果目前的趋势继续下去，这些挑战可能会压倒这些系统。在啮齿类动物中，饮食限制（DR）和营养和生长信号通路的突变可以延长30-50%的寿命，但也可以降低与年龄相关的功能丧失和疾病的发生率，包括肿瘤和神经变性。该申请要求资金支持共识研讨会“干预人类减缓衰老：我们准备好了吗？”“将于2013年10月8日至13日在意大利西西里埃里切举行。共识研讨会的主要目的是汇集老年学、药物发现和开发方面的主要专家，开始就发现和开发安全干预措施以减缓人类衰老和增加人类健康寿命达成共识。会议的目标是：1）确定最合适的候选健康干预措施/药物用于临床开发，2）提供一个论坛，讨论与衰老和年龄相关疾病相关的药物发现的最新技术，3）刺激临床试验，开始对基础老年医学研究产生的药物进行测试，并讨论每种药物的潜在缺陷和副作用。

DESCRIPTION (provided by applicant): Human aging and age-associated diseases are becoming one of the biggest challenges faced by developed and developing countries. The financial burden caused by these chronic diseases is already overwhelming and currently taxing the healthcare and welfare systems of developed nations, but if present trends continue, the challenges could overwhelm the systems. In rodents, both dietary restriction (DR) and mutations in nutrient and growth signaling pathways can extend longevity by 30-50% but also lower the incidence of age-related loss of function and disease, including tumors and neurodegeneration. This application requests funds to support the Consensus Workshop "Interventions to Slow Aging in Humans: Are We Ready?" to be held in Erice, Sicily, Italy, from October 8-13, 2013. The main aim of the consensus workshop is to bring together leading experts in gerontology, drug discovery and development to begin to obtain consensus related to the discovery and development of safe interventions to slow aging and increase healthspan in humans. The goals of the conference are: 1) To determine the most suitable candidate healthspan interventions/drugs for clinical development, 2) To provide a forum for the discussion of state of the art techniques for drug discovery related to aging and age-related disease, 3) To stimulate clinical trials to begin the testing of drugs generated by basic biogerontology research and discuss the potential pitfalls and side effects of each drug.