Aging and the immune system

描述（由申请人提供）：本R-13申请寻求部分支持卫星会议“衰老与免疫系统”与国际免疫学大会（ICI）将于2013年8月22日至27日在米兰举行。这次会议将汇集来自世界各地的科学家，包括美国和欧洲的科学家，他们的智力重点是衰老的免疫学。本次会议将于2013年8月20日至21日在米兰举行。在此，我们请求提供资金，以便美国的发言者参加会议。计划中的会议将提供一个极好的场所，就免疫系统老化研究的最新成就、基因组学（包括微生物组）使用的优势和局限性、该领域的方法发展和临床应用、制药公司的参与和疫苗开发等问题进行建设性的讨论。我们期望这次会议将大大有助于欧洲和美国在免疫老年学方面的研究结构更加整合和更好地协调。此外，我们认为，这次会议，特别是反对国际化学研究所的会议，将吸引新的研究人员和学员到该领域。这次会议将加强已经存在的合作，并支持创建新的转化研究，这将有利于人口老龄化。会场，米兰会议中心，MiCo，是欧洲最大的会议设施，于2011年开业，位于米兰市中心，因此可以方便地通过地铁到达，并且完全残疾人无障碍。会议的首要目标是总结近年来免疫学衰老的研究进展，讨论适应性免疫学、先天免疫学和临床应用免疫学等最重要的研究领域。第二个目标是引发一场关键性的讨论，讨论将这些发现应用于未来能够更好地帮助老年人的干预措施（疫苗）的优势、限制和潜在问题。将讨论最近的疫苗发展、预测反应性的生物标志物以及最近发现的干预措施。第三个目标是设计未来的战略(a)如何优化这一特定研究领域的互动、网络和合作，以及(b)如何组织欧洲和美国科学家之间的持续交流。从历史上看，美国免疫学和衰老的重点一直是小鼠系统，而在欧洲主要是人类。这次会议将使两个不同地理和学科小组更好地互动，并将为进一步加强免疫老年学作为基础免疫学中一个独特的、普遍接受的领域做出重大贡献。

DESCRIPTION (provided by applicant): This R-13 application seeks partial support for a Satellite Meeting "Aging and the Immune System" in conjunction with the International Congress of Immunology (ICI) to be held in Milan, August 22-27, 2013. This meeting will bring together scientists from all over the world including American and European scientists whose intellectual focus is the immunology of aging. This conference, will take place in Milan on August 20th and 21st, 2013. Here we request funds to allow participation by speakers from the United States. The planned conference will provide an excellent venue for constructive discussions on recent achievements in research on the aging immune system, advantages and limits of the usage of genomics, including the microbiome, as well as methodological development and clinical application in this field, participation from pharmaceutical companies and vaccine development. We expect that this meeting will significantly contribute to a more integrated and better-coordinated European and American research structure in immunogerontology. In addition, we believe that the meeting, particularly with its opposition to the ICI, will attract ne investigators and trainees to the field. This meeting will enforce already existing collaborations and support the creation of new translational studies which will benefit the aging human population. The venue, the Milan Congress Center, MiCo, is the largest conference facility in Europe, opened in 2011, located in downtown Milan and therefore easily accessible by Metrorail and fully handicap accessible. First goal of the meeting is to summarize recent progress in research on immunology of aging, addressing the most important research areas such as adaptive, innate and clinically applied immunology. The second goal is to trigger a critical discussion on the advantages, limits and potential problems of the application of these discoveries to future interventions which can better help the elderly (vaccines). Recent vaccine development, biomarkers to predict responsiveness, and recently discovered interventions will be discussed. The third goal is to design future strategies on (a) how to optimize interaction, networking and collaborations in this specific research field, and (b) how to organize continuous interchange between European and US scientists. Historically, the focus of immunology and aging in the US has been with murine systems, whereas in Europe has mainly been with humans. This meeting will allow better interaction not only of the 2 different geographical but also disciplinary groups, and will make a substantial contribution to further strengthen immunogerontology as a distinct, generally accepted field within basic immunology.