Integrated Training in Pharmacological Sciences

请参阅说明)： 西奈山药理学综合培训计划旨在提供严格的 跨学科的博士前训练，掌握控制生理和心理的基本机制 病理生理过程和药物作用。这项计划的目标是提供教育活动 以及研究培训，将基本的机械发现与治疗方式联系起来，包括 药物靶点的确定和铅治疗化合物的开发。培训计划的目的是为了 实现深入培训，同时具备广阔的视角，使学员能够融入新兴市场 在他们的职业生涯中都有新的领域。该计划还寻求创造一个学习环境，促进 独立思考和个人分析能力，同时培养协作工作能力 学习和研究环境。该计划结合了综合教学培训的核心 药理学和系统生物学，提供基础的核心原则的生物化学，结构 生理学和疾病病理生理学背景下的生物学、遗传学、细胞和分子生物学。 不同规模的系统问题的计算和建模方法、大型数据集和 流行病学问题贯穿始终，并提供支持，使学生能够 不同的入门级别的量化技能才能成功。本课程采用综合主动学习。 基础课程和高级课程的方法，通过具体的教学创新而得到加强。他们 包括非同步讨论以及课堂讨论和使用同行评价方法 为学生未来职业生涯的这一主要特点做好准备。参加此次培训的49名教职员工 该计划来自13个学术部门和研究所，包括临床和基础 强调科学。他们的研究项目为项目实习生提供了解决重要问题的机会 具有很强的药理学和/或系统生物学的生物医学不同领域的问题 界面和翻译潜力。跨学科和转化型培训环境和 该计划的结构促进了我们的受训人员进入独立的科学职业。 相关性(请参阅说明)： 产生改善不同人类疾病的新药的突破，产生新的诊断或 新的治疗策略越来越依赖于应用定量计算的研究人员 方法研究疾病与药物相互作用的复杂生物学。我们的目标是在人才培养中培养这些技能 博士生和医学博士/博士生，使他们实现下一代的突破。

See instructions): The Integrated Training in Pharmacological Sciences program at Mount Sinai aims to provide rigorous interdisciplinary pre-doctoral training in the fundamental mechanisms that control physiological and pathophysiological processes and drug action. It is the goal of this program to provide educational activities and research training that connect the basic mechanistic findings to therapeutic modalities including the identification of drug targets and development of lead therapeutic compounds. The training program seeksto achieve in-depth training coupled with a broad perspective that equips the trainees to incorporate emerging new areas throughout their careers. The program also seeks to create a learning environment that promotes independent thinking and individual analytical skills, while fostering the ability to work in collaborative learning and research environments. The program combines a core of integrated didactic training in Pharmacology and Systems Biology that provides grounding in core principles of biochemistry, structural biology, genetics, cellular and molecular biology within a context of physiology and disease pathophysiology. Computational and modeling approaches to systems problems at various scales, to large data sets and to epidemiological problems are introduced throughout, together with support that enables students with different entering levels of quantitative skills to succeed. This curriculum uses an integrated active learning approach in both basic and advanced courses that is enhanced by specific pedagogical innovations. They include asynchronous discussions as well as in-class discussions and use of peer evaluation methodologies that prepare students for this major feature of their future careers. The 49 participating faculty of this training program are drawn from 13 academic departments and institutes that include a mix of clinical and basic science emphases. Their research projects provide opportunities for program trainees to tackle important problems in diverse areas of biomedicine that have strong pharmacological and/or systems biology interfaces and translational potential. The interdisciplinary and translational training environment and the structure of the program foster the entry of our trainees into independent scientific careers. RELEVANCE (See instructions): Breakthroughs that yield new drugs that ameliorate different human diseases, that yield new diagnostics or new therapeutic strategies depend more and more upon researchers who apply quantitativecomputational methods to the complex biology of disease and drug interactions. We aim to foster these skills in talented PhD and MD/PhD students, enabling them to achieve the next generation of breakthroughs.