UCLA Center for AIDS Research (CFAR)

这项申请构成了加州大学洛杉矶分校(UCLA)对 艾滋病研究中心(CFAR)赠款。这笔赠款将资助由 加州大学洛杉矶分校艾滋病研究所内的CFAR。加州大学洛杉矶分校CFAR成立于1988年，艾滋病研究所 成立于1992年，旨在协调大学所有的艾滋病研究、临床和教育活动 以及它的七家附属教学医院归一个中央管理。委员会的整体组织结构 艾滋病研究所和CFAR于2005年进行了重组，以便更有效率和有效地管理 教职员工在过去五年中增加了30%，适用于CFAR的补助金增加了50% 自从我们提交了最后一次续签申请。此续订申请包括CFAR核心服务和 旨在通过基础、临床和行为方面提高对艾滋病毒/艾滋病的认识的活动 科学。加州大学洛杉矶分校CFAR的总体使命是在不同学科之间创造协同效应，从而 在认识、预防和治疗艾滋病毒感染方面取得重大突破，特别是 强调高价值的跨学科协作。加州大学洛杉矶分校CFAR由200多名教职员工组成 负责250多个研究项目的调查人员，这些项目几乎涵盖了 艾滋病毒/艾滋病生物学、临床研究和行为科学。加州大学洛杉矶分校一直位居 在艾滋病研究、教育和教学以及临床项目方面表现出色的顶尖学府。大都会 洛杉矶是艾滋病流行的主要震中，也是世界上文化最多元化的地区之一 国家，我们的计划旨在接触到这些不同的社区。我们特别自豪 近年来，我们临床试验中招募的患者中有50%是少数族裔社区的成员。 CFAR的作用是促进大学内外的合作和建立联系， 通过支持科学和行政核心设施，并提供种子赠款资金用于 极具价值的合作研究项目。 请求支助的第一年，即2008年1月至2008年12月的行动计划摘要如下 以下是：CFAR计划继续支持由上一次CFAR赠款资助的8个核心： 行政核心，发展核心，病毒学/BSL3组织培养核心，细胞计数核心， 鼠/人嵌合体核心，基因和细胞治疗核心，粘膜免疫学核心，以及 生物统计学核心。根据不断变化的流行病学、需求评估、战略规划和修订 短期和长期目标，取消了两个核心，一个临床研究促进核心和一个 添加了咨询核心。

This application constitutes a renewal on the part of the University of California/Los Angeles (UCLA) for a Center for AIDS Research (CFAR) grant. This grant will fund activities and programs conducted by the UCLA CFAR within the UCLA AIDS Institute. The UCLA CFAR was set up in 1988, and the AIDS Institute was established in 1992 to coordinate all AIDS research, clinical and educational activities at the University and its seven affiliated teaching hospitals under one central administration. The overall organization of the AIDS Institute and the CFAR was restructured in 2005, in order to more efficiently and effectively manage a faculty that has grown by 30% in the last five years and CFAR-applicable grants that have risen by 50% since we submitted our last renewal application. This renewal application includes CFAR core services and activities that are designed to advance knowledge of HIV/AIDS through the basic, clinical, and behavioral sciences. The overall mission of the UCLA CFAR is to create synergies among diverse disciplines that result in significant breakthroughs in the understanding, prevention and treatment of HIV infection¿with particular emphasis on high-value cross-disciplinary collaborations. The UCLA CFAR consists of more than 200 faculty investigators who are responsible for more than 250 research projects that encompass virtually all aspects of HIV/AIDS biology, clinical studies, and behavioral science. UCLA has consistently been ranked among the top institutions for excellence in AIDS research, education and teaching, and clinical programs. Metropolitan Los Angeles is a major epicenter for the AIDS epidemic and one of the most culturally diverse regions in the nation, and our programs are designed to reach out to these diverse communities. We are particularly proud that 50% of the patients recruited into our clinical trials in recent years are members of minority communities. The role of the CFAR is to foster collaboration and build linkages both within and outside the university, through support of scientific and administrative core facilities, and the provision of seed grant funding for highly meritorious collaborative research projects. The action plan for the first year of requested support, January 2008 to December 2008, is summarized as follows: The CFAR plans to continue supporting eight of the cores funded by the previous CFAR grant: Administrative Core, Developmental Core, Virology/BSL3 Tissue Culture Core, Cytometry Core, Mouse/Human Chimera Core, Gene and Cellular Therapy Core, Mucosal Immunology Core, and the Biostatistics Core. Based upon changing epidemiology, needs assessments, strategic planning and revised short- and long-term goals, two cores were eliminated and a Clinical Research Facilitation Core and a Consultation Core are added.