Pathogenesis of Calcium Nephrolithiasis

总体描述（由申请人提供）： 我们的研究涉及三个核心服务的三个项目中分布的具体目标。其中一些项目由于在本赠款期内发现了新的研究结果，目前正在进行中。其余为新项目。几乎所有的协议都依赖于至少两个项目之间的合作关系，并至少借鉴一个核心。Coe的项目在高度集中的临床研究中心（CRC）协议中使用人类受试者，旨在了解斑块，CD堵塞和结石形成的病理生理学，与喂养相关的激素和矿物质动力学。Lingeman的项目计划继续对我们尚未研究的许多SF表型进行定位和活检。 Evan计划继续对SF活检进行组织病理学和矿物质分析。我们计划一个关键的实验，以确定是否初始斑块的网站是上升或下降肢体的THL。我们将继续分析SF患者组的治疗结局和表型特征。

DESCRIPTION, OVERALL (provided by applicant): Our research involves specific aims distributed among three projects served by three cores. Of these, some are currently in progress as a result of new findings discovered during the present grant period. The remainder represent new projects. Almost all of the protocols depend upon collaborative relationships between at least 2 projects, and draw upon at least one core. Project by Coe uses human subjects in highly focused clinical research center (CRC) protocols aimed at understanding the pathophysiology of plaque, CD plugging and stone formation in terms of hormonal and mineral dynamics related to feeding. Project by Lingeman plans continued mapping and biopsy of the many SF phenotypes we have not yet studies. Project by Evan plans continued histopathologic and mineral analysis of SF biopsies. We plan a critical experiment to determine whether the initial plaque site is the ascending or the descending limb of the THL. We will continue to produce analyses of SF patient groups in terms of treatment outcomes and phenotype characterization.