Pathogenesis of Calcium Nephrolithiasis

总体描述(由申请人提供)： 我们的研究涉及分布在三个核心服务的三个项目中的特定目标。其中，由于在本赠款期间发现的新发现，其中一些目前正在进行中。其余的代表新项目。几乎所有的协议都依赖于至少两个项目之间的协作关系，并利用至少一个核心。COE项目在高度集中的临床研究中心(CRC)方案中使用人类受试者，旨在了解与喂养相关的激素和矿物质动力学方面的斑块、CD堵塞和结石形成的病理生理学。Lingeman项目计划继续对我们尚未研究的许多SF表型进行测绘和活组织检查。Evan Plans项目继续对SF活组织进行组织病理学和矿物分析。我们计划进行一项关键实验，以确定最初的斑块位置是THL的升支还是降支。我们将继续对SF患者群体的治疗结果和表型特征进行分析。

DESCRIPTION, OVERALL (provided by applicant): Our research involves specific aims distributed among three projects served by three cores. Of these, some are currently in progress as a result of new findings discovered during the present grant period. The remainder represent new projects. Almost all of the protocols depend upon collaborative relationships between at least 2 projects, and draw upon at least one core. Project by Coe uses human subjects in highly focused clinical research center (CRC) protocols aimed at understanding the pathophysiology of plaque, CD plugging and stone formation in terms of hormonal and mineral dynamics related to feeding. Project by Lingeman plans continued mapping and biopsy of the many SF phenotypes we have not yet studies. Project by Evan plans continued histopathologic and mineral analysis of SF biopsies. We plan a critical experiment to determine whether the initial plaque site is the ascending or the descending limb of the THL. We will continue to produce analyses of SF patient groups in terms of treatment outcomes and phenotype characterization.