NEI Mentored Clincial Scientist Development Program Award (K12)

这是一个机构培训补助金的建议，教育下一代的临床医生，科学家在眼科学术职位。38年来，杜克大学眼科中心（DUEC）一直是培养学术眼科医生的国家领导者。这些受训人员的最早一代现在在全国和国外的学术医疗中心担任许多领导职务。他们有作为院长，系主任和教师的角色，并作为导师的院士。我们建议通过一个旨在提供必要的指导，资源和教学，以生产临床科学家在眼科学术职位的强化计划继续这一传统。我们计划每年在完成眼科或病理学实习后选择两名学员进行为期3年的密集教育计划，这将导致独立的同行评审拨款资金和学术机构的教师职位。学员将接受密集的教学课程，并由杜克大学的高级教师进行密切的指导。每个学员将接受强制性培训，在临床研究，遗传学，统计学，科学写作，拨款准备，道德和负责任的研究行为领域。每个学员将参加重要的原创研究，并学习基本技能，以发展成功和独立的学术生涯。每个受训者课程的其他方面将由项目主任和首席导师根据选定的主要研究方向及其技能、背景和职业目标进行量身定制。我们 提出了五个主要的研究方向：（1）转化医学和临床试验，（2）临床和床旁到板凳，（3）眼科基因组学和蛋白质组学，（4）眼科病理学，（5）结果和卫生政策。由于眼科病理学家的国际短缺，我们将试图招募和适当的个人的研究生涯，涉及使用来自患者和实验模型的眼组织。

This is an institutional training grant proposal to educate the next generation of clinician-scientists for academic positions in Ophthalmology. For over 38 years, the Duke University Eye Center (DUEC) has been a national leader in training academic Ophthalmologists. The earliest generations of these trainees now serve in numerous leadership positions in academic medical centers across the country and abroad. They have roles as Deans, Department Chairs, and faculty members and serve as mentors for academicians. We propose to continue this tradition through an intensive program designed to provide the guidance, resources, and didactic teaching necessary to produce clinician-scientists for academic positions in Ophthalmology. We plan to select two trainees each year after their completion of a residency in Ophthalmology or Pathology for an intense 3 year educational program that will lead to independent peer-reviewed grant funding and a faculty position in an academic institution. The trainees will undergo an intensive didactic curriculum combined with a close mentorship by senior faculty at Duke University. Each trainee will receive mandatory training in areas of clinical research, genetics, statistics, scientific writing, grant preparation, ethics, and the responsible conduct of research. Each trainee will participate in significant original research and learn the essential skills to develop a successful and independent academic career. Additional aspects of the curriculum of each trainee will be tailored by the program director and lead mentor based upon the selected primary research track and his/her skills, background and career goals. We propose five primary research tracks: (1) translational medicine and clinical trials, (2) clinics and bedside to the bench, (3) Ophthalmic genomics and proteomics, (4) ophthalmic pathology, (5) outcomes and health policy. Because of an international shortage of Ophthalmic Pathologists we will attempt to recruit and appropriate individuals for a research career involving the use of ocular tissues derived from patients and experimental models.