2012 Mechanisms of Epilepsy and Neuronal Synchronization Gordon Research Conferen

描述(由申请人提供)：我们正在为2012年8月19-24日在新汉普郡沃特维尔山谷度假村举行的关于癫痫机制和神经元同步的戈登研究会议寻求NINDS的支持。癫痫研究的主要目的是确定神经元网络中同步放电的潜在机制，以便开发更有效的治疗癫痫的方法。癫痫研究的一个独特的、在智力上具有挑战性的方面源于这样一个事实，即它几乎涵盖了从基因和离子通道到电路和行为的所有主要生物组织水平。本次戈登研究会议的主要目的是将遗传学家、分子生物学家、发育神经学家、神经解剖学家、电生理学家和计算神经学家聚集在一起，研究与癫痫发生直接或间接相关的基本机制，以综合当前的进展，并为未来的发现奠定基础。本次会议的主题是癫痫脑中的功能重组，将涵盖的主题包括：1)癫痫的发生：我们能预防它吗？2)癫痫的产生：癫痫从哪里开始，如何开始？3)癫痫的电路分析和动力学：新的方法；4)中间神经元：癫痫的类型、控制和功能障碍；5)氯稳态：癫痫中有变化吗？6)发育性癫痫和共病：有共同的机制吗？7)癫痫脑中的通道重组：基因改变是否意味着治疗目标？我们的目标是传播最新的科学进展，促进富有成效的新见解和合作，激发年轻研究人员对癫痫研究的兴趣，并为新的翻译研究奠定基础，这些研究将在尽可能短的时间内为癫痫的治疗带来最新的发现。 与公共卫生相关：癫痫是一种慢性疾病，影响全球5000万人。开发新的治疗策略来更好地治疗并潜在地预防和治愈这种破坏性的疾病，需要科学进步来增加我们对导致癫痫的分子和细胞机制的理解。这次会议将把来自世界各地的专家聚集在一个密集、沉浸式的环境中，介绍和讨论新的发现，促进知识的传播，并促成合作。这将极大地推动旨在更好地治疗癫痫的研究。

DESCRIPTION (provided by applicant): We are requesting NINDS support for a Gordon Research Conference on Mechanisms of Epilepsy and Neuronal Synchronization to be held August 19-24, 2012, at Waterville Valley Resort in New Hampshire. The main goal of the study of seizures is to identify the mechanisms underlying synchronous electrical discharges in neuronal networks in order to develop more effective treatments and cures for epilepsy. A unique, intellectually challenging aspect of epilepsy research arises from the fact that it encompasses virtually all major levels of biological organization, from genes and ion channels to circuits and behavior. The major purpose of this Gordon Research Conference is to bring together geneticists, molecular biologists, developmental neuroscientists, neuroanatomists, electrophysiologists, and computational neuroscientists working on basic mechanisms related either directly or indirectly to seizure generation to synthesize current advances and set the stage for future discoveries. The theme of the current conference is Functional Reorganization in the Epileptic Brain, and the topics to be covered include: 1) Epileptogenesis: Can we prevent it? 2) Seizure generation: Where and how do seizures begin? 3) Circuit Analysis and Dynamics in Epilepsy: Novel approaches; 4) Interneurons: Types, control and dysfunction in epilepsy; 5) Chloride Homeostasis: Are there alterations in epilepsy? 6) Developmental Epilepsies and Co-morbidities: Are there common mechanisms? and 7) Channel Reorganization in the Epileptic Brain: Do genetic alterations suggest treatment targets? Our goals are to disseminate the latest scientific advances, foster productive new insights and collaborations, stimulate an interest in epilepsy research among young investigators; and set the stage for new translational studies that will bring the newest discoveries to the treatment of epilepsy in the shortest possible time. PUBLIC HEALTH RELEVANCE: Epilepsy is a chronic condition that affects 50 million people worldwide. Development of novel therapeutic strategies to better treat and potentially prevent and cure this devastating condition requires scientific advances to increase our understanding of the molecular and cellular mechanisms responsible for epilepsy. This conference will bring together experts from all over the world in an intensive, immersing environment to present and discuss novel findings, facilitate dissemination of knowledge and spawn collaborations. This should significantly advance research directed towards better treatment of epilepsy.