AMINISTRATIVE CORE

脑瘤孢子生物素/病理学核心提供致力于 通过使用优化的收集程序，提高脑肿瘤生物标本的完整性和可用性； 多种形式的保存、处理和分析；组织病理学-分子特征；以及 计算机化库存和基于网络的请求和跟踪系统。样本鉴定的所有方面， 加工和储存严格遵守美国病理学家学会(CAP)的规定 指导方针。为了最大限度地分享和整合孢子项目，组织核心收集和 使来自所有分布式脑肿瘤生物标本的数据可用。 孢子生物显微镜/病理学核心的具体目标： A.从手术室和孢子动物核获取脑肿瘤患者的生物标本 优化处理以最大化细胞存活率和/或最小化热缺血间隔，从而满足 脑肿瘤孢子项目和临床试验的组织应计要求。这一目标对于 所有项目。 B.对手术收集的脑肿瘤生物标本进行质量控制分析 房间和孢子动物核心，以确保有足够数量的一致处理 将为孢子项目和临床试验产生高质量数据的标本。 C.提供常规和先进的组织处理/处理和分析技术，包括 免疫组织化学、荧光原位杂交、组织芯片构建、DNA/RNA 提取、分离蛋白质和准备活细胞，这将推动项目假说的发展 和目标实现。 D.维护一个包含人口统计数据、分子分析结果和脑瘤的数据库 将链接到相关临床数据库的患者生物样本分布(内部和外部) 由生物统计和临床核心维护。 相关性(请参阅说明)： 脑瘤孢子Biospecimen/病理核心致力于优化人和动物 脑肿瘤生物样品收集、存储、使用、分发和共享来自使用该技术的研究的数据 宝贵的资源。核心对于每个脑瘤孢子的高影响翻译目标是必不可少的 项目。

The Brain Tumor SPORE Biospecimen/Pathology Core provides staff and technology dedicated to enhancing brain tumor biospecimen integrity and usability through use of optimized collection procedures; multi-modality preservation, processing, and analysis; histopathologic-molecular characterization; and computerized inventory and web-based request and tracking systems. All aspects of sample identification, processing and storage are performed with strict compliance to the College of American Pathologists (CAP) guidelines. In order to maximize sharing and integration of SPORE projects, the Tissue Core collects and makes available data derived from all distributed brain tumor biospecimens. Specific Aims of the SPORE Biospecimen/Pathology Core: A. To acquire brain tumor patient biospecimens from the operating room and SPORE Animal Core with optimized handling to maximize cell viability and/or minimize the warm-ischemic interval so as to meet the tissue accrual requirements for the Brain Tumor SPORE projects and clinical trials. This aim is essential for all Projects. B. To perform quality control assays on archived brain tumor biospecimens collected from the operating room and SPORE Animal Core, to ensure availability of adequate numbers of consistently handled specimens that will yield high quality data for SPORE projects and clinical trials. C. To provide routine and advanced tissue handling/processing and analytical techniques, including immunohistochemistry, fluorescence in situ hybridization (FISH), tissue microarray construction, DNA/RNA extraction, protein isolation, and preparation of viable cells thatwill advance project hypothesis development and goal attainment. D. To maintain a database containing demographic data, results from molecular analyses, and brain tumor patient biospecimen distributions (internal and external) that will be linked to relational clinical databases maintained by the Biostatistics and Clinical Core. RELEVANCE (See instructions): The Brain Tumor SPORE Biospecimen/Pathology Core is dedicated to the optimization of human and animal brain tumor biospecimen collection, storage, use, distribution, and sharing of data from studies using this precious resource. The Core is essential for the high impact translational goals of each Brain Tumor SPORE Projects.