Data Management and Coordinating Center (DMCC)

此应用程序寻求为数据管理和协调中心(DMCC)(以前称为 作为罕见病临床研究网络的数据技术协调中心 (RDCRN)。申请人Krischer博士在过去5年一直担任DTCC的首席调查员 几年来，并寻求续签支持罕见疾病的DMCC的合作协议 临床研究网络(RDCRN)。DMCC建议扩展系统、流程和 在上一个资助周期中成功地制定了程序，以容纳3000名登记在 32项当前研究，取决于相关临床研究的成功重新竞争 财团，增加反映网络增长的新研究，联合会的住宿 数据库，与已有基础设施(登记处、患者数据库等)的财团合作和 注册处为网上招聘提供一个用户友好的网站，每个网站的点击量超过340万次 目前，为寻求临床注册的受试者增强了4000多名成员的联系方式 审判。我们将继续开发新技术，以支持可伸缩性和通用性以及工具 用于跨疾病数据挖掘。我们的国际临床信息网络是安全的，提供协调的 用于收集、存储和分析来自多种疾病的不同数据类型的数据管理服务 和地理上不同的位置以及面向普通公众和更大的临床社区的门户 调查人员。

This application seeks funding for the Data Management and Coordinating Center (DMCC) (formerly known as Data Technology Coordinating Center, DTCC) for the Rare Diseases Clinical Research Network (RDCRN). The applicant, Dr. Krischer, has served as the Principal Investigator for the DTCC for the last 5 years and seeks to renew the cooperative agreement for the DMCC which supports the Rare Diseases Clinical Research Network (RDCRN). The DMCC propose to extend the systems, processes, and procedures developed successfully over the last grant cycle to accommodate the 3000 subjects enrolled on 32 current studies, contingent upon the successful re-competition of their associated clinical research consortia, addition of new studies reflecting the growth of the network, accommodation of federated databases, work with consortia that have pre-existing infrastructure (registries, patient databases, etc.) and registries, provide a user friendly website for web-based recruitment which receives over 3.4 million hits per year at present and a 4000+ member contact registry enhanced for subjects seeking enrollment on clinical trials. We will continue development of new technologies to support scalability and generalizability and tools for cross-disease data mining. Our international clinical information network is secure providing coordinated data management services for collection, storage and analysis of diverse data types from multiple diseases and geographically disparate locations and a portal for the general public and larger community of clinical investigators.