Core F: Canine Cell & Molecular Resources

核心F是一个开发中的核心，旨在产生犬特异性细胞和分子试剂， 增强犬模型用于新疗法临床前安全性和有效性测试的价值。作为 狗是一种大型的、寿命相对较长的、外繁殖的物种，它与人类有许多相似之处。具体而言， 对于造血和干细胞移植，狗模型已经高度预测了 人类患者，包括移植物抗宿主病的发展及其对治疗的反应。在 除了细胞系，组织，DNA和cDNA已经可用。核心F将产生犬特异性shRNA 用于击倒实验的图书馆。

Core F is a developing core designed to generate canine specific cell and molecular reagents to enhance the value of the canine model for preclinical safety and efficacy testing of new therapeutics. As a large, relatively long-lived, out bred specie, the dog has many similarities with humans. Specifically in regard to hematopoiesis and stem cell transplantation the dog model has been highly predictive of outcomes in human patients, including the development of graft-versus-host disease and its response to treatment. In addition to celllines, tissue, DNA, and cDNA already available. Core F will generate canine specific shRNA libraries for knock down experiments.