Allergy and Clinical Immunology Training Grant

描述（由申请人提供）：本申请是为了继续支持为博士后医学和儿科学员设计的过敏和临床免疫学培训计划。有一个双培训教师。首先，来自儿科，过敏和临床免疫学，流变学，肺，胃肠病学，皮肤病学，传染病和人类转化免疫学医学系的临床研究人员。第二，导师，他们是基础科学家，主要来自耶鲁大学杰出的免疫生物学系。他们的专业知识几乎涵盖了过敏、临床免疫学和现代免疫学的所有重要领域;包括：体液、细胞、分子、遗传、生物化学、抗原加工/呈递和信号研究。一些教师是莱姆病的专家，这是耶鲁大学在这个培训项目中发现的。我们继续用siRNA治疗蜱虫，以了解发病机制并开发疫苗。在过敏和临床免疫学方面有严格的培训，以及流变学，皮肤病学，胃肠病学，肺和ENT的免疫学方面的一些培训教师配备了主要仪器，包括：优秀的流式细胞术，寡核苷酸合成仪，蛋白质测序仪以及阵列和深度cDNA测序（Illumina/Solexa）。这是一个小型的高质量的培训计划，每年只招收一名新研究员，拥有大量的教师，强调需要至少3-5年的实验室研究，为我们专注的研究医学职位做好准备。教师有很强的培训记录和协作研究互动。研究员们第一年从事临床活动。第二年和第三年完全在免疫生物学教师导师的研究项目中，同时参加各种免疫生物学和临床科学课程，参加每周研讨会和期刊俱乐部，并定期就他们的研究和感兴趣的免疫学/过敏主题进行演讲。 总之，该计划为未来的学术医学和儿科职位提供了独特和非常高质量的优秀候选人培训，并且在30多年的持续资助中取得了相当成功。

DESCRIPTION (provided by applicant): This application is for the continued support of a training program in Allergy and Clinical Immunology that is designed for postdoctoral medical and pediatric trainees. There is a double training faculty. Firstly, clinician-researchers from Pediatrics, the Department of Medicine in Allergy and Clinical Immunology, Rheumatology, Pulmonary, Gastroenterology, Dermatology, Infectious Diseases and Human Translational Immunology. Secondly, Mentors, who are basic scientists mainly from Yale's outstanding Department of Immunobiology faculty. Together, their expertise spans nearly all of the areas important to allergy, clinical immunology, and modern immunology; including: humoral, cellular, molecular, genetic, biochemical, antigen- processing/presenting, and signaling research. Some faculty are experts in Lyme disease, which was discovered at Yale by faculty in this training program. We continue with siRNA treatment of ticks to understand pathogenesis and develop vaccines. There is rigorous training in Allergy, and Clinical immunology, and some in Immunologic aspects of Rheumatology, Dermatology, Gastroenterology, Pulmonary, and ENT. The training faculty is well equipped with major instruments including: outstanding flow cytometry, oligonucleotide synthesizer, protein sequinator and access to array and deep cDNA sequencing (Illumina/Solexa). This is a small high quality training program, taking only one new fellow per year, with a large faculty emphasizing the need for at least of 3-5 years of laboratory research to prepare trainees for positions in research medicine, upon which we are focused. The faculty have a strong training record and collaborative research interactions. The fellows spend their first year in clinical activities. The second and third years entirely in a research project under an Immunobiology faculty mentor, while taking various immunobiology and clinical science courses, participating in weekly seminars and journal clubs, and regularly giving talks on their research, and immunologic/allergy subjects of interest. In summary, the program offers unique and very high quality training of outstanding candidates for future positions in academic medicine and pediatrics, and has been quite successful in this regard over more than 30 years of continuous funding.