An ontology for pain and related disability, mental health and quality of life.

描述（由申请人提供）：该项目的目标是更好地了解疼痛障碍的复杂性，特别是关于不同类型疼痛的评估以及疼痛相关残疾及其与心理健康和生活质量的关系。这将通过开发一个本体论来实现，该本体论将用于整合五个现有的数据集，这些数据集广泛涵盖了发生在口腔和相关区域的主要疼痛类型（口面部疼痛、颞下颌紊乱疼痛、头痛），并结合了一系列与疼痛的生物心理社会学观点相一致的测量方法。主诉单一区域性持续性疼痛的患者通常表现出一种以上疼痛障碍的症状。目前，尽管仍不确定，疼痛领域认为不同类型的疼痛来自不同的机制。因此，患有特定类型持续性疼痛的患者接受的治疗是基于这种疼痛的分类，可能是不恰当的。数据集涵盖了相同的领域，但在各个方面都是不同的：(1)一些变量在数据集中是相同的，其他涉及，例如躯体化，抑郁和焦虑，是不同的，因为用不同的工具测量；(2)数据粒度不同；(3)由于其不同的起源（美国、英国、瑞典、以色列和德国），这些数据集包含了与疼痛报告相关的文化影响，尽管使用了共同的工具，但这些影响对数据集的可比性有影响。本体将使以统一和正式的方式描述数据集成为可能，并且足够通用，以便在同一领域中包含其他可用的数据集。这一努力的重要性在于它对解决一个重要问题的贡献，即许多疼痛状况的表型在范围、自然历史和/或感兴趣的疾病亚群的临床过程方面没有充分定义，最重要的是，在实验室研究提供重要病理见解的疾病特征方面。通过合并这些数据集，我们将能够回答的主要临床问题是病理解剖学和病理生理学-在这种情况下，在TMD和口面部疼痛的背景下-如何影响疼痛相关的残疾和生活质量。由于本体论将提供心理健康领域广泛使用的评估工具的正式表示，因此，由于实际原因，其适用性将远远超过拟议项目所涵盖的更狭窄的领域。该本体将按照开放生物医学本体铸造（OBO-Foundry）中广泛接受并在自然中发表的原则构建，使用基本形式本体（BFO）和参考跟踪（RT）作为通用语义技术。通过与国际RDC/TMD联盟网络以及国际疼痛研究协会的口腔面部疼痛特别兴趣小组的合作，该本体很可能成为该领域的标准。

DESCRIPTION (provided by applicant): The goal of this project is to obtain better insight into the complexity of pain disorders, specifically concerning the assessment of different pain types as well as pain-related disablement and its association with mental health and quality of life. This will be achieved by developing an ontology which will then be used to integrate five existing datasets that broadly encompass the major types of pain (orofacial pains, temporomandibular disorder pain, headache) recognized to occur in the oral and associated regions and incorporating a broad array of measures consistent with a biopsychosocial perspective regarding pain. Patients complaining of a single regional persistent pain typically manifest symptoms suggestive of more than one pain disorder. Presently, and although still uncertain, the pain field regards different types of pain as emerging from different mechanisms. Consequently, patients suffering from a given type of persistent pain receive treatments based on how that pain has been classified, perhaps inappropriately. The datasets cover the same domain, but are distinct in various respects: (1) some variables are identical across datasets, others involving, for instance, somatization, depression and anxiety, are different because measured with distinct instruments; (2) the data exhibit different levels of granularity; (3) because of their distinct origins (US, UK, Sweden, Israel, and Germany), the datasets incorporate cultural influences related to pain report that have an impact on the comparability of the data sets, despite the use of common instruments. The ontology will make it possible to describe the datasets in a uniform and formal way, and be general enough to include other datasets in the same domain once they become available. The importance of this endeavor lays in its contribution to solving an important problem, namely that the phenotype of many pain conditions is insufficiently defined in terms of the scope, the natural history and/or clinical course of the disease subgroup of interest, and, most importantly, with respect to disease traits for which laboratory research has provided important pathogenetic insight. The main clinical question that we will be able to answer by merging these datasets is how patho-anatomy and pathophysiology - in this case in the context of TMD and orofacial pains - have an impact on pain-related disablement and quality of life. Because the ontology will provide a formal representation of widely used assessment instruments in the domain of mental health, its applicability will exceed by far the more narrow domain that is covered in the proposed project for practical reasons. The ontology will be built following the widely accepted and in Nature published principles adhered to in the Open Biomedical Ontology Foundry (OBO-Foundry, using Basic Formal Ontology (BFO), and Referent Tracking (RT) as generic semantic technologies. By working in collaboration with The International RDC/TMD Consortium Network, and the Orofacial Pain Special Interest Group of the International Association for the Study of Pain, this ontology is likely to become a standard in the domain. PUBLIC HEALTH RELEVANCE: There is general consensus that combined biomedical and biopsychosocial methods best support the assessment and management of pain and dysfunction caused by musculoskeletal disorders and the impact thereof on mental health and quality of life. The ontology to be developed in the proposed effort embodies the conceptual theories underlying relevant biomedical models (anatomy and pathophysiology related to temporomandibular joints), psychological models and biopsychosocial models. It thus supports an integrated and multidimensional approach concerning physical and psychosocial factors involved in pain and dysfunction, and will help in the conceptualization and management of pain-related disorders for various health care professionals.