Text Messaging to Improve Adherence to Oral Chemotherapy Agents

描述(由申请人提供)： 这项学术研究促进奖提案的目的是进行一项关于短信的小规模、与健康相关的研究项目，以提高口服化疗药物的依从性。密歇根州立大学护理学院(MSU-CON)一直不是国家卫生研究所拨款的主要接受者。因此，这项建议的总体目标是加强护理学院的研究环境，使其能够发展成为一个重要的与健康相关的科研企业。这个项目将涉及本科生和研究生，从而激发学生以研究为职业的兴趣。为这项提议计划的研究的重要性如下。目前市场上有50多种口服药丸形式的化疗药物，预计在3年内，25%的癌症治疗将以药丸形式提供。口服制剂有许多相关的好处，如方便、避免去诊所就诊，以及减少对日常活动的影响。要使口服药物达到癌症治疗的有效水平，患者必须严格遵守治疗方案。口腔抗癌药物的依从性通常不到80%，这可能不足以治疗癌症。更复杂的是，近75%的癌症患者还患有自我护理管理责任的共病，这可能会对口服制剂的依从性造成障碍。到目前为止，在提高口服药物依从性方面的实证研究还不够发达。这项研究的目标是通过一种基于技术的策略：定制短信服务(SMS)来提高口服化疗药物的依从性。这项为期10周、两组的前瞻性随机对照试验将从三个癌症中心招募75名患者(干预组50名，对照组25名)，以检查为期三周的定制短信干预的可行性、可接受性和满意度，以确保口服制剂的依从性。将使用描述性统计、广义线性建模和广义估计方程进行分析。在这项提案中，将收集初步数据来检查短信干预促进口服制剂依从性的有效性。然后，数据将被用来进一步为开发干预措施提供信息，以提高R01应用的口服药物的依从性，以进行更大规模的随机试验，以测试这一创新干预措施。这项研究可以通过开发一种基于技术的策略来促进越来越多的接受药丸形式癌症治疗的癌症患者的依从性，从而对口服制剂的依从性产生革命性的影响。这种新型干预也有可能改变和影响许多其他需要坚持药物治疗方案的患病人群。此外，这项建议涉及许多护理学生，使他们成为一个团队的全面运作的成员，并让他们参与研究过程。这一应用将加强密歇根州立大学CON的研究环境，使其能够发展成为与健康相关的重要科研企业。

DESCRIPTION (provided by applicant): The purpose of this Academic Research Enhancement Award proposal is to conduct a small-scale, health- related research project on text messages to improve adherence to oral chemotherapy agents. Michigan State University College of Nursing (MSU-CON) has not been a major recipient of National Institute of Health grant funding. As a result, the overall objectiveof this proposal is to strengthen the research environment in the College of Nursing so that it can develop into a significant health-related scientific research enterprise. This project would involv undergraduate and graduate students and, thus, generate student interest in research as a career. The importance of the research planned for this proposal is as follows. More than 50 oral chemotherapy agents in pill form are currently on the market, with projections that in 3 years, 25% of cancer treatments will be delivered in pill form. There are many associated benefits of oral agents, such as convenience, avoidance of clinic visits, and reduced impact on daily activities. For oral agents to achieve a - therapeutically effective level for cancer treatmet, patients must strictly adhere to the regimen. Adherence to oral cancer agents is often less than 80%, which may be inadequate for treating the cancer. To further complicate this, nearly 75% of those with cancer also have comorbid conditions with self-care management responsibilities, which may create barriers to oral agent adherence. To date, empirical research in the area of improving adherence to oral agents is underdeveloped. The goal of this research is to improve adherence to oral chemotherapy agents through a technology-based strategy: tailored short message service (SMS) text messages. This 10 week, two group, prospective randomized controlled trial will enroll 75 patients (50 in the intervention group and 25 in the control group) from three cancer centers to examine the feasibility, acceptability, and satisfaction with a three week, tailored, text message intervention for oral agent adherence. Descriptive statistics, generalized linear modeling, and generalized estimating equations will be used for analysis. In this proposal, preliminary data will be collected to examine efficacy of the text message intervention to promote adherence to oral agents. Data will then be used to further inform the development of an intervention to improve adherence to oral agents for an R01 application to conduct a larger randomized trial to test this innovative intervention. This study can have a transformative impact on oral agent adherence by developing a technology-based strategy to promote adherence among the increasing number of cancer patients who receive their cancer treatment in pill form. This type of novel intervention also has the potential to transform and impact many other ill populations that require adherence to a medication regimen. Furthermore, this proposal involves numerous nursing students, allowing them to be fully functioning members of a team and engaging them in the research process. This application will strengthen the research environment at MSU- CON so that it can develop into a significant health-related scientific research enterprise.