2013 Cerebellum Gordon Research Conference

描述（由申请人提供）：该提案为第二届两年一次的小脑戈登研究会议（GRC）寻求部分支持，该会议将于2013年8月在美国新罕布什尔州新伦敦的科尔比-索耶学院举行。小脑是调节运动和执行复杂行为（如行动顺序）的大脑区域。它的功能障碍与运动障碍有关，包括共济失调、肌张力障碍和运动障碍，以及认知障碍，包括阅读障碍和自闭症谱系障碍。小脑研究跨越了许多层面的分析，包括分子生物学、遗传学、细胞生理学、系统生理学、解剖学、行为学、计算学和临床方法。尽管许多从事小脑研究的研究人员有共同的研究问题和科学目标，但他们很少有机会作为一个群体与应用不同方法研究小脑在正常和病理生理条件下如何工作的共同问题的研究人员会面并讨论他们的工作。小脑GRC的目的是为小脑研究人员提供展示和讨论他们的假设、结果和发现的场所；汇集来自不同职业阶段和不同背景的科学家，否则他们不太可能有机会密切互动；并发展科学关系，这将导致合作工作和研究小脑健康和疾病的新方法。这些目标将通过9场由领域领导者和崭露头角的初级研究人员进行的口头报告、充足的讨论时间（积极促进年轻科学家和学员的参与）、海报展示（最大程度地展示所有与会者的研究）以及科学会议之间的非结构化时间（进行深入、自发的讨论）来实现。包括小脑疾病的动物模型、人类小脑功能和研究小脑的新兴技术等会议，不仅可以促进健康的思想交流，而且还可以教育研究人员了解他们的工作如何与神经和精神疾病的治疗有关，并最好地发挥作用。

DESCRIPTION (provided by applicant): The proposal seeks partial support for the second biennial Gordon Research Conference (GRC) on the Cerebellum, to be held at Colby-Sawyer College in New London, NH, USA, in August 2013. The cerebellum is a brain region that regulates movements and carries out complex behaviors such as sequencing of actions. Its dysfunction is associated with motor disorders, including ataxias, dystonia, and dyskinesia, as well as cognitive impairments, including dyslexia and autism spectrum disorder. Cerebellar research spans many levels of analysis, encompassing molecular biological, genetic, cellular physiological, systems physiological, anatomical, behavioral, computational, and clinical approaches. Although many researchers engaged in the study of the cerebellum have common research questions and scientific goals, they have few opportunities to meet as a group and discuss their work with investigators who apply diverse methodologies to the common question of how the cerebellar works in normal and pathophysiological conditions. The aims of the Cerebellum GRC are to provide the venue for cerebellar researchers to present and discuss their hypotheses, results, and discoveries; to bring together scientists from multiple career stages and different backgrounds, who otherwise would be unlikely to have the opportunity to interact closely; and to develop scientific relationships that will lead to collaborative work and new approaches to investigating the cerebellum in health and disease. These aims will be achieved by 9 sessions of oral presentations by leaders in the field and up-and-coming junior investigators, ample discussion time with active facilitation of participation by young scientists and trainees, poster presentations for maximal exposure of all attendees' research, and unstructured time between scientific sessions for in-depth, spontaneous discussions. Inclusion of sessions, such as animal models of cerebellar disease, human cerebellar function, and emerging technologies to study the cerebellum promise, not only generate a healthy exchange of ideas but also educate investigators about how their work pertains to and can best be brought to bear on the treatment of neurological and mental disorders.