Discovery to Implementation & Back: Research Translation for the HIV/SU Epidemic

描述(申请人提供)：这是毒品使用和艾滋病毒研究中心的续签申请。我们这次更新的重点将是“从发现到实施再回到：艾滋病毒/物质(SU)流行病的研究翻译”。我们目前的中心专注于与艾滋病毒和药物使用有关的跨学科研究。在此期间，该中心经历了调查员人数的增长(目前设在4个机构)，这为协同作用和协作提供了新的机会，调查员为这一领域作出了许多重大贡献。然而，艾滋病毒的发病率、发病率和死亡率仍然处于令人无法接受的高水平，药物使用仍然是减少发病率和健康差距、获得护理和最大限度地发挥护理效益的关键障碍。药物使用者仍然非常脆弱和受到歧视，重视药物使用在流行病中的作用对于我们实现国家艾滋病毒/艾滋病战略的目标(即减少新的感染、改善与艾滋病毒有关的健康结果和减少与艾滋病毒有关的健康差距)至关重要。此外，有必要加快研究转化过程(从发现到对公共健康的影响)，并纳入关于影响这一流行病的迅速变化的背景的知识，包括生物医学进步和社会经济变化。为了创建基础设施来应对这些挑战，我们对此次续订的范围和核心结构进行了重大更改。该中心更新的总体目标是：(1)提高研究的质量和影响，以支持国家卫生行动计划的目标；(2)加强项目的研究转化工作；(3)使项目能够纳入对艾滋病毒物质使用流行病产生影响的背景变化的研究。我们将通过6个核心实现这些目标：1个行政核心和5个研究支助核心：(1)跨学科理论综合和发展；(2)传染病和生物医学；(3)跨学科研究方法；(4)比较有效性研究；(5)试点项目和指导。这些核心将努力提高调查人员之间的协同作用和生产力，并刺激新倡议、新调查人员和新知识的发展，以影响艾滋病毒物质使用流行病。

DESCRIPTION (provided by applicant): This is a renewal application for the Center for Drug Use and HIV Research. Our focus in this renewal will be "From Discovery to Implementation and Back: Research Translation for the HIV/Substance (SU) Epidemic". Our current Center focused on interdisciplinary research related to HIV and substance use. During this period the Center experienced a growth in investigators (now located at 4 institutions) that provided new opportunities for synergy and collaboration, and investigators made many significant contributions to the field. However, HIV incidence, morbidity and mortality remain at unacceptably high rates, and substance use remains a critical barrier to reducing incidence and health disparities, accessing care, and maximizing the benefits of care. Substance users remain highly vulnerable and stigmatized, and a focus on the role of substance use in the epidemic is vital to our achieving the goals of the National HIV/AIDS Strategy (NHAS) (i.e., to reduce new infections, improve HIV-related health outcomes and reduce HIV-related health disparities). In addition, there is a need to expedite the research translation process (from discovery to public health impact) and to incorporate knowledge about the rapidly changing contexts that impact the epidemic, including biomedical advances and socio-economic changes. To create an infrastructure to address these challenges, we have made significant changes in our scope and Core structure for this renewal. The overarching aims of this Center renewal are to: (1) enhance the quality and impact of research to support the goals of the NHAS; (2) enhance projects' research translation efforts; and (3) enable projects to incorporate the study of the contextual changes influencing the HIV-substance use epidemic. We will achieve these aims through 6 Cores: an Administrative Core and 5 Research Support Cores: (1) Transdisciplinary Theoretical Synthesis and Development; (2) Infectious Diseases and Biomedical; (3) Transdisciplinary Research Methods; (4) Comparative Effectiveness Research; and (5) Pilot Projects and Mentoring. These Cores will work to enhance synergy and productivity across investigators, and stimulate the development of new initiatives, new investigators and new knowledge to impact the HIV-substance use epidemic.