Molecular mechanisms and novel therapeutic approaches to combined radiation and b

摘要 我们将在两个模型中研究中等剂量辐射的联合损伤， 阶段研究。在第一阶段，我们将使用匿名的手术样本， 烧伤离体研究基因和蛋白质表达差异，开发一种 非侵入性测定，以预测成功的伤口愈合，并测试β肾上腺素能 受体拮抗剂作为改善伤口愈合的潜在疗法。在第二阶段， 我们将在小鼠模型中研究类似的问题。因此，总的研究将联合收割机 人类数据（然而，其不是体内的）和来自完整动物的数据（其是体内的）。 体内），以获得相关信息，可以告知更好的发展 机械理解伤口愈合的机制，在存在 辐射损伤，并开发潜在的治疗方法，以后可以在临床上进行测试。

Abstract We will investigate combined injury by moderate dose radiation in two models in a two- phase study. In the first phase, we will use anonymized surgical samples irradiated and wounded ex vivo by burning to study gene and protein expression differences, develop a non-invasive assay to predict successful wound healing, and test a beta adrenergic receptor antagonist as potential therapy to improve wound healing. In the second phase, we will investigate similar issues in a mouse model. Thus, the total study will combine human data (which is, however, not in vivo) and data from intact animals (which is in vivo) to obtain relevant information that can inform the development of a better mechanistic understanding of the mechanisms of wound healing in the presence of radiation damage, and to develop potential therapies that can later be tested in the clinic.