Biological Correlates of Traumatic Stress

描述（由申请人提供）：这是J.道格拉斯布雷姆纳医学博士在面向患者的研究（K24）“创伤应激的生物学相关性”中的职业中期研究者奖续期申请，使他能够继续在创伤压力的生物相关性领域为初级调查人员提供指导。申请人的研究已经将脑成像应用于创伤后应激障碍（PTSD）的研究，使用磁共振成像（MRI）显示PTSD中海马体积较小，并且使用正电子发射断层扫描（PET）显示PTSD中涉及内侧前额叶皮质、海马和杏仁核的神经回路的改变。申请人的其他研究应用了显示5-羟色胺再摄取抑制剂（SSRI）促进神经发生（其被应激抑制）的动物发现，以显示SSRI导致海马体积增加5%和基于海马的陈述性记忆功能改善30%。目前的研究正在使用成像来研究创伤后应激障碍治疗反应的神经相关性以及应激和抑郁的神经和心肌相关性。申请人在进行研究方面非常富有成效，并在他的早期职业生涯中指导了43名学员，并在K24的第一阶段与他的T32“神经影像科学培训计划（TPINS）”一起。神经影像科学培训计划（TPINS），埃默里大学神经科学研究生课程和其他资源，包括疾病控制中心（CDC），行为神经科学中心和耶基斯地区灵长类动物中心，代表了研究和学员发展的绝佳机会。埃默里大学有一种学院和协作的氛围，为学员创造了极好的体验。埃默里大学在美国排名前25位的大学中，少数民族学生和教师的比例最高，为少数民族提供了一个极好的培训机会。申请人提供的导师将提供一批重要的新的研究人员，在创伤压力的生物相关性领域进行下一代研究。

DESCRIPTION (provided by applicant): This is an application for a renewal of Mid-Career Investigator Award in Patient Oriented Research (K24) "Biological Correlates of Traumatic Stress" for J. Douglas Bremner, M.D., to allow him to continue to provide mentoring to junior investigators in the area of biological correlates of traumatic stress. Studies by the applicant have applied brain imaging to the study of posttraumatic stress disorder (PTSD), using magnetic resonance imaging (MRI) to show smaller hippocampal volume in PTSD, and positron emission tomography (PET) to show alterations in a neural circuit involving medial prefrontal cortex, hippocampus and amygdala in PTSD. Other studies by the applicant applied animal findings showing that serotonin reuptake inhibitors (SSRIs) promote neurogenesis (which is inhibited by stress) to show that SSRIs result in a 5% increase in hippocampal volume and 30% improvement in hippocampal-based declarative memory function. Current studies are using imaging to study neural correlates of response to treatment in PTSD and neural and myocardial correlates of stress and depression. The applicant has been very productive in performing research and has mentored 43 trainees during his early career and in the first period of this K24 in conjunction with his T32 "Training Program in Neuroimaging Sciences (TPINS)". The Training Program in Neuroimaging Sciences (TPINS), Graduate Program in Neuroscience at Emory, and other resources, including the Center for Disease Control (CDC), Center for Behavioral Neuroscience, and Yerkes Regional Primate Center, represent excellent opportunities for research and the development of trainees. There is a collegial and collaborative atmosphere at Emory that creates as excellent experience for trainees. Emory University has the highest proportion of minority students and faculty of any of the top 25 universitites in the US, offering an excellent opportunity for training in an area particularly relevant for minorities. The mentorin provided by the applicant will provide an important new crop of investigators to conduct the next generation of research in the field of biological correlates of traumatic stress.