Preclinical Development of mPGES-1 & 5-LOX selective inhibitors for Colon Cancer

每年有15万美国人被诊断患有结直肠癌，这是美国癌症相关死亡的第二大原因。在过去的二十年中，临床前和临床研究以及广泛的机制研究支持炎症介质的重要性，特别是那些衍生的花生四烯酸代谢，在许多上皮癌，特别是在结直肠癌的进展。

Every year 150,000 Americans are diagnosed with colorectal cancer, the second leading cause of cancer-related mortaliy in the US. Over the past two decases, preclinical and clinical studies and extensive mechanistic studies support the importance of inflammatory mediators, particulary those derived for arachidonic acid metabolism, in the progression of many epithelial cancers, particularly in colorectal cancer.