2012 Neurobiology of Brain Disorders GRC

描述（由申请人提供）：本提案要求部分支持在马萨诸塞州伊斯顿的斯通希尔学院举行的戈登研究会议系列的一部分，即关于脑疾病神经生物学的会议。会议将于2012年8月5日至10日举行。该研讨会的具体目的是汇集处于神经退行性疾病和神经发育疾病领域最前沿的领先科学家，介绍和讨论他们的最新发现和概念。会议将讨论与疾病机制相关的广泛但相关的主题，如突触功能障碍，自噬，蛋白质错误折叠和聚集，线粒体生物学和RNA结合蛋白。特邀演讲者代表了各种科学学科，包括遗传学，生物化学，细胞生物学，电生理学和成像技术。将尽一切努力鼓励研究生、博士后研究员和初级教员以及妇女和少数群体成员参与。会议将为年轻科学家提供机会，在海报展示会上介绍他们的工作，并与该领域的领导人进行非正式互动。此外，将从提交的海报中选择简短的演讲，因此年轻的科学家将有机会参加口头报告。学院的氛围和下午和深夜的充足自由时间为来自不同学科的参与者提供了理想的环境，以集思广益并建立跨学科的合作。该应用程序的意义在于，该GRC将为致力于脑疾病神经生物学的国际社会提供一个独特的论坛，聚集在一起讨论该领域的最新进展和未来挑战。该应用程序与公共卫生的相关性在于，所产生的讨论将有助于在基本生物学和疾病机制方面定义神经退行性疾病和神经发育疾病领域中剩余的重要问题，这将有助于为这些破坏性疾病开发新的治疗策略，这些疾病是主要的公共卫生问题。该研究中心的长期目标是为社区提供一个一致的平台，定期（每两年）开会，以传播最新的发现，并制定大脑疾病研究所面临的最重要的问题。 公共卫生相关性：神经退行性疾病和神经发育疾病是日益严重的公共卫生问题;例如，仅阿尔茨海默病就代表发达国家老年人死亡的第四大原因。本次戈登研究会议旨在汇集研究这些大脑疾病的基础生物学和疾病机制的科学家，讨论最新进展并确定未来的重要问题。戈登会议是一个理想的场所，允许与会者免费展示和讨论未发表的数据及其影响，并制定未来的挑战，以更好地了解疾病机制和开发新的治疗策略。

DESCRIPTION (provided by applicant): This proposal requests partial support for a meeting on the Neurobiology of Brain Disorders as part of a Gordon Research Conference series to be held at Stonehill College in Easton, Massachusetts. The meeting will take place between August 5th and 10th, 2012. The Specific Aim of this GRC is to bring together leading scientists who are at the forefront of the field of neurodegenerative and neurodevelopmental diseases to present and discuss their latest findings and concepts. The Conference will feature a wide range but related topics that are relevant to disease mechanisms, such as synaptic dysfunction, autophagy, protein misfolding and aggregation, mitochondrial biology, and RNA-binding proteins. Invited speakers represent a wide variety of scientific disciplines, including genetics, biochemistry, cell biology, electrophysiology and imaging technology. Every effort will be made to encourage participation of graduate students, postdoctoral fellows and junior faculty members as well as women and members of minority communities. The Conference will provide opportunities for junior scientists to present their work in the poster sessions and to interact informally with leaders in the field. In addition, short talks will be selected from the submitted posters, so junior scientists will have opportunities to participate in oral presentations. The collegial atmosphere and the ample free time in the afternoons and late evenings provide ideal settings for participants from different disciplines to brainstorm and establish interdisciplinary collaborations. The significance of this application is that this GRC will provide a unique forum for the international community working on the neurobiology of brain disorders to come together and discuss the latest advances and the future challenges in the field. The relevance of this application to public health is that the discussions generated will help define the remaining important questions in the field of neurodegenerative and neurodevelopmental diseases in terms of both basic biology and disease mechanisms, which will aid the development of novel therapeutic strategies for these devastating diseases that are major public health problems. The long-term goal of this GRC is to provide a consistent platform for the community to meet regularly (every two years) in order to disseminate the most recent discoveries and to formulate the most important questions facing research on brain disorders. PUBLIC HEALTH RELEVANCE: Neurodegenerative and neurodevelopmental diseases are growing public health problems; for example, Alzheimer's disease alone represents the 4th leading cause of death among the elderly in developed countries. This Gordon Research Conference intends to bring together scientists who work on basic biology and disease mechanisms of these brain disorders to discuss the latest advances and define future important questions. The Gordon Conference is an ideal venue that allows participants to present and discuss freely unpublished data and their implications as well as formulate future challenges for better understanding disease mechanisms and developing novel therapeutic strategies.