Membrane Protein Folding

描述（由申请人提供）：申请资金用于支持生物物理学会主办的“膜蛋白折叠专题会议”。由于其在生物学中的核心作用，蛋白质折叠在过去的50年里一直是分子生物学的一个主要话题。然而，关于膜蛋白折叠的研究却出奇地有限。虽然在蛋白质折叠中有许多会议，但膜蛋白甚至不包括在内是很常见的。因此，我们对这些重要蛋白质及其相关的错误折叠疾病的理解仍然存在重大差距。会议的目标是通过专门讨论这一主题来促进这一尚处于起步阶段的领域的发展。为了促进该领域的国际参与，我们将在韩国首尔的韩国高等研究院（KIAS）举行会议。大多数参与者将被安置在KIAS的森林校园里，我们将在KIAS的自助餐厅一起用餐，这将促进互动。许多会议在KIAS举行，因此他们在举办会议方面有相当多的专业知识，他们也将为这次会议提供慷慨的财政支持。我们将汇集一群对膜蛋白折叠问题既有实际兴趣又有基础兴趣的科学家。虽然重点是蛋白质折叠问题的生物物理方面，但我们已经包括了一个关于错误折叠疾病的会议，并包括了三个关于膜在衰老疾病，帕金森病和阿尔茨海默病中的作用的讲座。我们还结合了多种技术，包括单分子实验，核磁共振，晶体学，计算预测和设计，分子动力学模拟，折叠热力学和动力学的实验分析，定向进化的稳定性，和体内折叠。这个小组应该与参与者进行热烈的讨论，他们将对这个问题提出许多不同的观点。我们对吸引和支持下一代科学家进入这一领域非常感兴趣，所以我们从海报演讲者中挑选了一些演讲，他们通常是更年轻的研究人员。我们还将通过在午餐时增加“主题桌”来促进对年轻科学家的指导，鼓励年轻研究人员与资深研究人员坐在一起。在某种程度上，我们非常希望通过这项拨款申请，为参加会议的青年科学家提供支持。

DESCRIPTION (provided by applicant): Funds are requested to support a Biophysical Society sponsored "Thematic Meeting on Membrane Protein Folding." Because of its central role in biology, protein folding has been a major topic in molecular biology over the last 50 years. Yet work on membrane protein folding has been surprisingly limited. While there are many meetings in protein folding, it is common that membrane proteins are not even included. As a result there remains a major gap in our understanding of these important proteins and their associated misfolding diseases. The goal of the meeting is to foster the development of this still fledgling field by devoting a meeting entirely to the topic. To promote international participation in the field, we will hold the meeting at the Korea Institute for Advanced Study (KIAS) in Seoul, South Korea. Most of the participants will be housed on the forested KIAS campus and we will take meals together in the KIAS cafeteria, which will facilitate interactions. Many conferences are held at KIAS so they have considerable expertise in running meetings and they will also provide generous financial support for this meeting. We will bring together a group of scientists who have both practical and fundamental interest in the problem of membrane protein folding. While the focus is on biophysical aspects of the protein folding problem, we have included a session on misfolding diseases and have included three talks on the involvement of membranes in the aging diseases, Parkinson's and Alzheimer's. We have also incorporated diverse techniques including single molecule experiments, NMR, crystallography, computational prediction and design, molecular dynamics simulations, experimental analysis of the thermodynamics and kinetics of folding, directed evolution for stability, and in vivo folding. This group should make or a lively discussion with participants who will bring many different perspectives to the problem. We are very interested in attracting and supporting the next generation of scientists to this field so we have incorporated a number of talks that will be selected from poster presenters, who are traditionally more junior investigators. We will also facilitate the mentoring of young scientists y adding "topic tables" at lunches where young investigators will be encouraged to sit with senior investigators. In part, through this grant application, we very much hope to provide support for junior scientists to come to the meeting.