SBIR TT - Transcatheter Cerclage Mitral Valve Annulopasty for Secon

本研究的目的是评估经导管二尖瓣成形术矫正二尖瓣二次返流的可行性。在过去的几年中，很少有经导管治疗二尖瓣反流的方法出现。这些方法通过冠状窦植入装置。尽管一些系统显示出潜在的主要障碍是冠状动脉压迫。根据一些研究数据，超过50%的患者有潜在的冠状动脉压迫风险，这是可能的

The purpose of this research is to evaluate the feasibility of transcatheter based mitral valve annuloplasty for correcting secondary mitral valve regurgitation. Few transcatheter based therapy for the treatment of mitral regurgitation has emerged rapidly over the past few years. These methods implant the device via Coronary Sinus. Although some of the systems showed potential a major obstacle is coronary artery compression. Based on some study data, over 50% of the patient has a potential coronary compression risk and it can be high as 68 %. NIH researchers have developed a method that consists of a novel method of anchoring the Cerclage band and also coronary protection device. This is a significant improvement over previous methods where patient selection was a major issue. During this feasibility phase a mature catheter system will be developed to consolidate the method developed by NIH researchers. This will improve the efficacy and determine the commercialization potential.