Rapid point-of-care detection of genomic variations for personalised medicine

根据一个人的基因特征选择治疗方法可以提高药物的安全性和有效性，但目前基于实验室的检测方法的不便、结果周转缓慢和成本高昂阻碍了其应用。在临床实践中全面实施个性化医疗需要一个护理点式测试系统。该项目旨在通过验证新的快速基因分型方法和开发超灵敏的实时DNA检测来克服开发此类系统所涉及的挑战，该检测将集成在单个芯片平台上，以促进小型、低成本和可靠的测试设备。这项技术将很容易适应迅速获得基因组信息有价值的领域，如疾病诊断和风险预测。

Selecting treatment based on a person’s genetic profile can improve drug safety and efficacy, but the application is hampered by the inconvenience, slow result turnaround and high cost of current lab-based tests. Full implementation of personalised medicine in clinical practice requires a point-of-care testing system. This project aims to overcome the challenges involved in developing such a system by validating novel rapid genotyping methods and developing ultrasensitive real-time DNA detection that will be integrated on a single chip platform to facilitate a small, low cost and reliable test device. The technology will be readily adaptable to areas where prompt access to genomic information is valuable, such as disease diagnosis and risk prediction.