2013 Stochastic Physics in Biology GRC

描述（由申请人提供）：本提案要求部分支持国际，跨学科的生物随机物理GRC会议。这是新戈登研究会议的第二部分，将于2013年1月13日至18日在加州文图拉举行。长期目标是将实验生物学家与物理科学家、工程师和应用数学家聚集在一起，以一种新的、随机的动态描述来更好地理解细胞的行为、功能和进化，在分子细胞生物学和进化生物学之间提供一条通道。第二次会议的具体目的是介绍生命过程随机动力学描述的基础，并讨论当前生物医学研究的趋势，揭示细胞分子波动，非线性反馈和不同时间尺度下的紧急行为。将有27位演讲者和9位会议主席。一些是有重大贡献的领先分子生物学家，另一些是活跃在前沿的年轻研究人员。这次会议将把这群不同的科学家聚集在一起，帮助建立这门新兴的新学科。研究人员将在介观尺度上讨论与细胞如何在噪声和波动的存在下功能、发展和进化有关的基本问题、方法和原理。这一应用的意义在于通过这次新的会议开发了一种新的细胞过程随机动力学描述，它将为来自物理和生物学科的研究人员提供一个长期的场所。因此，这次会议将有助于支持美国国立卫生研究院最近宣布的两项新倡议，旨在通过将物理科学家与生物科学家聚集在一起解决生物医学的重要问题，“架起科学的桥梁”。该应用的健康相关性在于更好地理解基础生物学，并帮助实现系统生物学在生物医学中的潜力。

DESCRIPTION (provided by applicant): This proposal requests partial support for an international, interdisciplinary conference on Stochastic Physics in Biology GRC. This is the 2nd installment of a new Gordon Research Conference, which will be held January 13 - 18, 2013 in Ventura, California. The broad long-term goal is to bring experimental biologists together with physical scientists, engineers and applied mathematicians to better understand the cellular behavior, function and evolution in terms of a new, stochastic dynamic description, provide a conduit between molecular cellular and evolutionary biology. The specific aim of this second meeting is to introduce the foundations for stochastic dynamical descriptions of living processes, and to discuss the trend of current biomedical research, which reveals cellular molecular fluctuations, nonlinear feedbacks, and emergent behaviors at different time scales. There will be 27 speakers and 9 session chairs. Some are leading molecular biologists with significant contributions, other are active young researchers at the leading edge. The meeting will bring together this diverse group of scientists to help establish this emerging new discipline. Researchers will discuss fundamental questions, approaches, and principles relating to how cells function, develop and evolve in the presence of noise and fluctuations at the mesoscopic scale. The significance of this application is in developing a new stochastic dynamical description of cellular processes through this new meeting that will provide a long-running venue to bring together researchers from physical and biological disciplines. Thus, this meeting will help support two new NIH initiatives, recently announced, that aim to "bridge the sciences", by bringing physical scientists together with biological scientists to solve problems of biomedical importance. The health relatedness of the application is in better understanding fundamental biology and in helping to realize the potential of systems biology in biomedicine.