Inhibitors of Src family kinase signalling

白血病-癌细胞改变了生物化学特性，导致其与正常细胞相比的高生长速率。其中之一是被称为酪氨酸激酶的酶的活性增强，包括Src家族的成员。其中一种叫林恩的与几种白血病和癌症有关。我们已经确定了一种新的机制，下调这个家庭的酶介导的小蛋白。这些可能使我们能够开发新的癌症-白血病治疗方法。

Leukaemia-cancer cells have altered biochemical properties resulting in their high rate of growth compared to normal cells. One of these is augmented activity of enzymes called tyrosine kinases including members of the Src family. One called Lyn has been implicated in several leukaemias as well as cancer. We have identified a novel mechanism of down-regulating this family of enzymes mediated by small proteins. These may allow us to develop novel therapeutics for cancer-leukaemia treatment.