Integrated Training in Reproductive Sciences

描述(由申请者提供)：该培训计划为从事生殖生物学研究工作的医生和科学家做准备。在其25年的历史中，该项目已培训了74名博士后研究员和研究生。该计划是多方面的，基础广泛。研究培训由生殖科学中心(CRS)的25名成员提供，他们在12个部门和组织的研究单位担任教职。该学院在生殖生物学方面拥有广泛的科学专长和活动，包括：生殖细胞发育、减数分裂、卵泡成熟、子宫内膜和胎盘功能的调节、激素作用机制、分子遗传学、类固醇生物合成和作用、子宫内膜和胎盘功能、正常和异常生殖功能的内分泌调节、多囊卵巢综合征的基础和临床研究。可用的技术包括：人类和小鼠胚胎学、转基因小鼠、胚胎干细胞、人类遗传学和基因组学、微阵列和蛋白质组学、蛋白质和小分子的质谱学、体外受精、整体动物生理学、前瞻性临床研究。在正式申请CRS或适当的研究生课程后，学员由招生委员会挑选。研究生继续攻读博士学位的课程。博士后培训将提供给相关学科的博士候选人，以及曾接受过专业培训的临床医学博士科学家。除了他们的研究工作，学员还参加规定的学术课程、研讨会、期刊俱乐部、会议和关于负责任的研究行为的研讨会。学员学习设计和执行基础研究项目，分析数据，并为著名的同行评议期刊撰写手稿。学员准备并提交校外资助申请，为独立的学术生涯做好准备。学员的学术发展由指导委员会通过个人发展计划来保证；学员的成功和培训计划通过对校友的年度调查来跟踪。该计划的优势包括：1)教师的不同技能和兴趣，2.)3.教师的互动性。)我们雄厚的实验室资源，以及4.)加州大学旧金山分校在生殖、发育、内分泌学、细胞生物学、遗传学及相关领域的卓越研究环境。 公共卫生相关性：人类生殖影响到所有世代，但妇女健康中的基本生物学和临床问题仍然存在许多问题。该项目整合了基础科学和临床研究方面的教员，旨在培养研究人员同时研究基础和临床人类生殖生物学，以改善妇女和儿童的健康。

DESCRIPTION (provided by applicant): This Training Program prepares physicians and scientists for investigative careers in reproductive biology. During its 25 year history, the program has trained 74 postdoctoral fellows and graduate students. The program is multifaceted and broadly based. Research training is provided by 25 members of the Center for Reproductive Sciences (CRS) who hold faculty positions in 12 departments and organized research units. The Faculty have a broad range of scientific expertise and activities in reproductive biology, including: germ cell development, meiosis, follicular maturation, regulation of endometrial and placental function, mechanisms of hormone action; molecular genetics, steroid biosynthesis and action, endometrial and placental function, endocrine regulation of normal and abnormal reproductive function, basic and clinical studies of PCOS. Technologies available include: human and mouse embryology, transgenic mice, embryonic stem cells, human genetics and genomics, microarrays and proteomics, mass spectrometric analysis of proteins and small molecules, in vitro fertilization, whole animal physiology, prospective clinical investigation. Following formal application to the CRS or to an appropriate graduate program, trainees are selected by an Admissions Committee. Graduate students pursue a course of study leading to the Ph.D. degree. Postdoctoral training will be offered to Ph.D. candidates in related disciplines, and to clinically trained M.D. scientists with prior specialty training. In addition to their research work, trainees take prescribed academic courses, seminars, journal clubs, conferences, and seminars on the responsible conduct of research. Trainees learn to design and execute basic research projects, analyze data and write manuscripts for prominent peer-reviewed journals. Trainees prepare and submit grant applications for extramural funding, preparing them for independent academic careers. Trainee academic development is assured by mentoring committees through individual development plans; success of trainees and the training program is tracked through yearly surveys of alumni. The strengths of the program include: 1.) the diverse skills and interests of the faculty, 2.) the interactiveness of the faculty, 3.) our substantial laboratory resources, and 4.) the outstanding environment for research in reproduction, development, endocrinology, cell biology, genetics and related areas at UCSF. PUBLIC HEALTH RELEVANCE: Human reproduction affects all generations, yet many questions remain concerning both the basic biology and clinical issues in women's health. This program integrates faculty in basic science and clinical investigation and seeks to train investigators to study both basic and clinical human reproductive biology to improve the health of women and children.