2011 ASN Improving Design and Conduct of Pragmatic Trials and Clinical Studies in

描述(申请人提供)：美国肾脏学会(ASN)年会，也被称为“肾脏周”，是世界上最大的在肾脏病领域工作的临床和转化性研究人员和基础科学家的聚会。在肾脏周的头两天，ASN赞助了一系列密集的研讨会，包括为期两天的“肾脏病流行病学、比较有效性和临床研究”年度研讨会，面向临床研究人员、研究生、博士后研究员、职业生涯早期和中期的院士、执业医生和专职医疗保健专业人员。本次研讨会的主题领域由ASN研究生教育(PGE)委员会开发和彻底审查，反映了翻译和临床调查的重要和时间敏感的领域，在肾脏疾病及其相关心血管疾病的管理中具有重要的临床和公共卫生影响。今年的研讨会将题为“改善肾脏病实用试验和临床研究的行为和设计”，将于2011年11月8日和9日在宾夕法尼亚州费城的费城会议中心举行。研讨会将有36名资深研究人员参加，他们大多是临床研究和对照试验领域的世界级领导者，他们将就以患者为中心的研究和转化性研究的设计和实施的不同方面发表演讲，重点是务实试验和实践结合研究。涵盖的主题将包括回顾最近和当前正在进行的NIDDK试验、务实的临床试验、基于实践的研究和集群试验、包括在退伍军人管理环境中的护理点试验、贝叶斯适应性设计随机化、罕见肾脏疾病试验、CKD和AKI的2型翻译研究及其对社区的影响、正在进行的NIDDK试验的辅助研究、数据收集前瞻性研究、生物标记物研究、生物库和人体标本存储、将患者相关结果用作试验终点、技术和设备开发试验、以及与临床研究相关的伦理问题，包括负责任的研究行为。选定的主题也与NIH路线图和以患者为中心的结果研究所(PCORI)的目标一致，以促进对社区健康产生直接影响的临床和转化性研究。在这次会议上，ASN成员和其他感兴趣的参与者将有机会与该领域的世界领导人互动。这项资助申请的目的是为初级教师和早期职业研究人员、博士后研究员和研究生申请旅行奖励资金，以便他们能够在ASN年度费城肾脏周的前两天参加这次会议。这次研讨会是与NIDDK的肾脏泌尿和血液科(KUH)合作举办的。少数族裔和妇女在规划委员会和特邀教员中都有很好的代表性，并计划赞助少数族裔和妇女以及残疾个人参加旅行补助金和其他活动。

DESCRIPTION (provided by applicant): The annual meeting of the American Society of Nephrology (ASN), also known as the "Kidney Week", is the largest gathering in the world of clinical and translational investigators and basic scientists working in the field of nephrology. During the first two days of the Kidney Week, the ASN sponsors a series of intensive symposia including a 2-day annual symposium on "Epidemiology, Comparative Effectiveness and Clinical Studies in Nephrology" for clinician investigators, graduate students, post-doctoral fellows, early- to mid-career academicians, practicing physicians and allied health care professionals. The subject area of this symposium is developed and reviewed thoroughly by the ASN's Post-Graduate Education (PGE) Committee and reflects important and time-sensitive areas of translational and clinical investigations with important clinical and public health implications in the management of kidney diseases and their related cardiovascular morbidities. This year's symposium will be titled "Improving Conduct and Design of Pragmatic Trials and Clinical Studies in Nephrology" and held during the upcoming ASN Kidney Week on November 8 and 9, 2011, in Philadelphia Convention Center, Philadelphia, PA. The symposium will feature 36 established investigators, who are mostly recognized as world class leaders in clinical studies and controlled trials and who will speak on diverse aspects of design and conduct of patient-centered and translational studies with focus on pragmatic trials and practice aligned studies. The topics covered will include review of recent and currently ongoing NIDDK-sponsored trials, pragmatic clinical trials, practice based studies and cluster trials, point-of-care trials including in Veterans Administrations settings, Bayesian adaptive design randomization, rare kidney disease trials, type 2 translational research in CKD and AKI and their implications for the community, ancillary studies to ongoing NIDDK trials, data collection prospective studies, biomarker studies, bio-banking and human specimen storage, use of patients-related outcomes as trial endpoints, technology and device development trials, and relevant ethical topics related to clinical studies including the responsible conduct of research. The selected topics are also consistent with the NIH roadmap and the objectives of the Patient-Centered Outcome Research Institute (PCORI) to promoted clinical and translational investigation with immediate impact on community health. At this conference, ASN members and other interested participants will have the chance to interact with world leaders in the field. The purpose of this grant application is to request funds for travel awards for junior faculty and early career investigators, postdoctoral fellows, and graduate students, so that they can attend this conference during the first 2 days of the ASN annual Kidney Week in Philadelphia. The symposium is in collaboration with the Kidney Urology and Hematology (KUH) Division of NIDDK. Minority and women are well represented among both planning committee and invited faculty members, and there are plans to sponsor minority and women as well as individuals with disabilities for the travel grants and other activities.