Innate immune functions of the intracellular antibody receptor TRIM21

免疫系统可以用抗体对抗病毒感染，抗体会在细胞外标记病毒，以便被免疫细胞清除。被抗体包裹的病毒试图通过隐藏在细胞内来逃避消灭。该项目将确定免疫细胞如何识别“隐藏”在它们体内的抗体包被病毒，以及它们发起的防御反应来消除病毒感染。这些知识可以让我们开发出更好的抗病毒药物和疫苗来对抗像普通感冒这样的病毒性疾病。

The immune system can fight viral infections with antibodies, which mark viruses outside of cells for elimination by immune cells. Antibody-coated viruses try to escape elimination by hiding inside cells. This project will determine how immune cells recognise the antibody-coated viruses ‘hiding’ within them, and the defence response they launch to eliminate viral infection. Such knowledge may allow us to develop better anti-viral drugs and vaccines to fight viral diseases like the common cold.