Evaluation of the Role of PSA Inhibitors in the Prevention and/or Therapy of

前列腺癌细胞，像正常的前列腺分泌腔上皮细胞一样，产生非常高水平的 PSA。前列腺特异性抗原（PSA）这个名字很恰当，因为它只由前列腺细胞产生高水平的PSA， 由人类男性的任何其他正常组织大量产生。PSA是一种胰凝乳蛋白酶样 丝氨酸蛋白酶被广泛用作筛选前列腺癌的生物标志物，以检测复发 在局部治疗后和对转移性疾病的全身治疗的反应后。然而，PSA 也是前列腺癌的公认治疗靶点。PSA作为生物标志物的作用 也许已经使

Prostate cancer cells, like normal prostate secretory-luminal epithelial cells, produce very high levels of the PSA. PSA is aptly named, in that it is produced at high levels exclusively by prostate cells and is not produced in significant amounts by any other normal tissue in the human male. PSA is a chymotrypsin-like serjne protease that is used extensively as a biomarker to screen for prostate cancer, to detect recurrence following local therapies and to follow response to systemic therapies for metastatic disease. PSA, however, is also a well credentialed therapeutic target for prostate cancer. The focus on PSA's role as a biomarker has made perhaps made