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Inhibitors and Probes of HIV-1 Cell Fusion

Inhibitors and Probes of HIV-1 Cell Fusion
HIV-1 细胞融合的抑制剂和探针
批准号：
8741404
负责人：
Carole Bewley
金额：
$79.44万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8741404
关键词：
AntigensBinding SitesBiochemicalBiological FactorsCarbohydratesCell fusionDevelopmentGlycoproteinsGoalsHIV Envelope Protein gp120HIV-1ImmobilizationLocal MicrobicidesMediatingNMR SpectroscopyNational Institute of Diabetes and Digestive and Kidney DiseasesNatural Products ChemistryPeptidesProteinsResolutionTechniquesVaccinesbasecarbohydrate binding proteindesigninhibitor/antagonistinterestnovelreceptorreceptor bindingsmall molecule

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中文摘要
翻译
NIDDK的天然产物化学部分，LBC，有几个正在进行的项目，其长期目标是鉴定和设计HIV-1包膜介导的细胞融合抑制剂和探针。这些研究包括设计和开发新的gp41衍生肽和蛋白质，它们具有抑制剂和免疫原的双重功能，发现和高分辨率结构表征新的碳水化合物结合蛋白，通过碳水化合物介导的gp120/gp41相互作用有效抑制HIV-1的进入，发现HIV-1融合的天然产物抑制剂，以及HIV-1包膜辅助受体相互作用的结构和机制研究。
英文摘要
The Natural Products Chemistry Section, LBC, NIDDK has several ongoing projects whose long term aim is to identify and design inhibitors and probes of HIV-1 Envelope-mediated cell fusion. These include the design and development of new gp41-derived peptides and proteins that have dual functions as inhibitors and immunogens, discovery and high resolution structural characterization of new carbohydrate binding proteins that potently inhibit HIV-1 Entry through carbohydrate-mediated interactions with gp120/gp41, discovery of natural product inhibitors of HIV-1 fusion, and structural and mechanistic studies of HIV-1 Envelope - coreceptor interactions.
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Discovery of Natural Products and Natural Product-Like Inhibitors
NMR Facility Management and Application of NMR Spectroscopy
Inhibitors and Probes of HIV-1 Cell Fusion
Discovery of Natural Products and Natural Product-Like Inhibitors
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