Role of CDC14B in mouse oocyte maturation

单倍体配子是有性繁殖所必需的，它是由前二倍体前体细胞通过 减数分裂。在雌性卵母细胞中，卵母细胞经历两次主要的减数分裂特有的细胞周期转变，其调控如下 人们对此知之甚少。第一个转变是减数分裂的恢复，卵母细胞退出长时间的前期停滞 并进入第一个减数分裂M期(M1)，第二个是m1和mil之间的过渡，其中 同源染色体分离，没有一轮DNA合成发生。 这个项目是在PI(Karen Schindler饰)担任加州大学博士后研究员时开始的 在宾夕法尼亚州，他促进了向独立研究职业的过渡。这些研究调查了 导致雌性卵子非整倍体的分子机制将形成一个独立的 新泽西州立大学罗格斯大学遗传学系的研究计划 PI将于2012年1月担任终身教职。罗格斯大学用于研究的环境 生殖生物学和非整倍体突出，完成研究所需的所有资源是 该机构致力于促进发展新的调查员。因此，PI将 做好准备，争取额外的资金，并拥有成功的独立研究事业。

Haploid gametes, that are essential for sexual reproduction, are generated fronn diploid precursor cells via meiosis. In females, oocytes undergo 2 major meiosis-specific, cell-cycle transitions wtiose regulation are poorly understood. Thie first transition is meiotic resumption where oocytes exit a prolonged prophase arrest and enter the first meiotic M phase (Ml), and the second is the transition between Ml and Mil where homologous chromosomes separate and no round of DNA synthesis occurs. This project began while the PI (Karen Schindler) was a postdoctoral fellow at the University of Pennsylvania and has facilitated transition to an independent research career. These studies investigating the molecular mechanisms that lead to aneuploidy in female eggs will form the basis of an independent research program in the Department of Genetics at Rutgers, The State University of New Jersey where the PI will assume a tenure-track faculty position in January 2012. The environment at Rutgers for research in reproductive biology and aneuploidy is outstanding, all resources required to complete the studies are available, and the institution is committed to promoting development of new investigators. Thus, the PI will be well-positioned to compete for additional funding and to have a successful independent research career.