Insulin resistance in Polycystic Ovary Syndrome and the role of skeletal muscle and adipose tissue

11%的女性患有多囊卵巢综合征（PCOS），其特征是胰岛素抵抗、月经不规律和不孕。这些女性容易患肥胖症、糖尿病和潜在的心脏病。治疗方法包括改变生活方式+药物治疗。生活方式是最重要的，但最佳的饮食运动处方尚不清楚。这项研究将为多囊卵巢综合征的病因提供见解，将告知运动在治疗中的作用，并可能确定未来治疗的目标。

11% of women have polycystic ovarian syndrome(PCOS), characterised by insulin resistance, irregular periods and infertility. These women are prone to obesity, diabetes and potentially, heart disease. Treatments include lifestyle modifications +-- medical therapy. Lifestyle is first line, yet the best diet-exercise prescription is unclear. This study will provide insights into the cause of PCOS, will inform on the role of exercise in therapy and may identify targets for future therapies.