Immunobiology of Blood and Vascular Systems Training Program

描述（由申请人提供）：本次重新提交的续期申请要求继续支持范德比尔特大学血液和血管系统免疫生物学（IBVSTP）的成熟，充满活力和富有成效的培训计划。IBVSTP专注于炎症作为疾病的主要机制，炎症可以显著改变血液和血管系统，以应对各种微生物、自身免疫和代谢损伤。这个创新的培训平台为研究生（包括双学位学生）和博士后提供指导和职业发展，已经证明了它的有效性，这一点得到了快速增长的富有成效的合作和来自8个基础科学和临床部门的21名教员研究人员的成果出版物的证明。这一名册允许IBVSTP促进炎症介导疾病的细胞和分子研究转化为创新疗法的临床前研究。自成立以来，为教师导师和学员在专题“亲和小组”内的有效互动建立了一个迄今尚未存在的平台，其中包括：(1)先天免疫和败血症和肺部/心血管感染中的炎症；(2)动脉粥样硬化、自身免疫、高血压、代谢综合征和移植中的促炎T和B淋巴细胞信号和基因表达；(3)造血细胞的发育、运输和粘附；(4)炎症和自身免疫的细胞外基质模型；(5)功能基因组学、表观遗传学、蛋白质组学、结构生物学以及用于蛋白质组修复的细胞内肽/蛋白质递送

DESCRIPTION (provided by applicant): This resubmission of the renewal application requests continued support for a well-established, vibrant and productive Training Program in the Immunobiology of Blood and Vascular Systems (IBVSTP) at Vanderbilt University. IBVSTP is focused on inflammation as the major mechanism of diseases that significantly alter blood and vascular systems in response to diverse microbial, autoimmune, and metabolic insults. This innovative training platform for mentoring and career development of graduate students, including dual degree students, and postdoctoral fellows has proven its effectiveness as attested by a rapidly growing number of fruitful collaborations and resulting publications from 21 faculty investigators who represent 8 basic science and clinical departments. This roster allows IBVSTP to facilitate translation of cellular and molecular studies of inflammation-mediated disorders into preclinical studies of innovative therapies. Since its inception, a hitherto non-existent platform was formed for effective interactions of faculty preceptors and trainees within thematic "affinity groups" encompassing: (1) Innate immunity and inflammation in sepsis and pulmonary/cardiovascular infections; (2) Proinflammatory T and B lymphocyte signaling and gene expression in atherosclerosis, autoimmunity, hypertension, metabolic syndrome, and transplantation; (3) Hemopoietic cell development, trafficking, and adhesion; (4) Extracellular matrix modeling in inflammation and autoimmunity; and (5) Functional genomics, epigenetics, proteomics, structural biology, and intracellular peptide/protein delivery for proteome restoration therapy. Since its prior renewal in 2006, these conceptual and cutting edge technological resources have provided tremendous opportunities for enhanced hands-on research experience and career development to 14 predoctoral and 19 postdoctoral trainees, including those from underrepresented groups. The Program's flagship course "Functional Genomics and Proteomics: Applications to Immunobiology" provides the unifying didactic platform. The institutional course on Responsible Conduct of Research is complemented by the Program-specific discussion groups. By requesting 5 predoctoral and 5 postdoctoral trainee slots, we respond to a growing demand for training from the Academic Community. The IBVSTP Steering Committee applies stringent admission criteria for selection of training candidates, including emphasis on translational goals of proposed projects, and evaluates trainees' performance. Postdoctoral trainees with Ph.D. and/or M.D. degrees are appointed following review by the IBVSTP Steering Committee and are advised by mentoring teams that represent the Program's Affinity Groups. The input of External Advisors and Consultants and a continuing feedback from trainees provide additional training quality checkpoints that enhance the Program's strong record of preparing the next generation of investigators in fundamental, translational, and clinical research focused on inflammation as the major mechanism of diseases affecting blood and vascular systems.